INT20611

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Context Info
Confidence 0.65
First Reported 1990
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 55
Total Number 58
Disease Relevance 23.71
Pain Relevance 14.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 12
urine 2
nerve 2
DRG 2
dorsal 1
Asap1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 356 99.98 Very High Very High Very High
intrathecal 61 99.98 Very High Very High Very High
Antinociceptive 286 99.80 Very High Very High Very High
Inflammation 289 99.64 Very High Very High Very High
Inflammatory response 39 99.44 Very High Very High Very High
antinociception 90 99.40 Very High Very High Very High
Antihyperalgesic 97 99.12 Very High Very High Very High
dorsal root ganglion 309 98.52 Very High Very High Very High
antiallodynic 88 98.28 Very High Very High Very High
Spinal cord 355 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperlipoproteinemia Type Ii 141 100.00 Very High Very High Very High
Pulmonary Disease 90 100.00 Very High Very High Very High
Apnoea 83 100.00 Very High Very High Very High
Pancreatitis 58 100.00 Very High Very High Very High
Pulmonary Alveolar Proteinosis 5 100.00 Very High Very High Very High
Nociception 287 99.84 Very High Very High Very High
Nervous System Injury 117 99.84 Very High Very High Very High
Cancer 68 99.84 Very High Very High Very High
Atherosclerosis 59 99.72 Very High Very High Very High
INFLAMMATION 326 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERI-1 contains a SAP domain found in DNA binding proteins and a DEDDh-like 3?
Gene_expression (domain) of a SAP
1) Confidence 0.65 Published 2006 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737212 Disease Relevance 0.05 Pain Relevance 0
These results suggest that the increase of serum PAP levels in patients with gastrointestinal cancers reflects an ectopic expression of PAP in cancer cells and that increased serum levels of PAP in acute pancreatitis are correlated with the disease severity and are prolonged than those of other pancreatic markers.
Gene_expression (expression) of PAP associated with cancer, pancreatitis, gastrointestinal neoplasms and disease
2) Confidence 0.65 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10389686 Disease Relevance 1.42 Pain Relevance 0.09
Of these, only the Biømeda antibody detected PAP in mouse DRG neurons and axon terminals [17].
Gene_expression (detected) of PAP in neurons
3) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.08 Pain Relevance 0.06
In addition, PAP was expressed in a majority of nonpeptidergic, isolectin B4-binding (IB4+) nociceptive neurons and a subset of peptidergic, calcitonin gene-related peptide-containing (CGRP+) nociceptive neurons.
Gene_expression (expressed) of PAP in neurons associated with nociception and calcitonin gene-related peptide
4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2800773 Disease Relevance 0.27 Pain Relevance 0.05
PAP was expressed in a majority of all nonpeptidergic neurons and a subset of peptidergic nociceptive neurons in the mouse [17].
Gene_expression (expressed) of PAP in neurons associated with nociception
5) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.22 Pain Relevance 0.14
Our studies with PAP/TMPase in mice, combined with previous studies on TMPase in rats, suggested PAP should be present in rat DRG neurons.
Gene_expression (present) of PAP in neurons
6) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.12 Pain Relevance 0.17
PAP was not changed in the combined therapy group, but increased in the patients receiving epinephrine alone.
Neg (not) Gene_expression (changed) of PAP
7) Confidence 0.59 Published 1990 Journal J Cardiothorac Anesth Section Abstract Doc Link 2151889 Disease Relevance 0 Pain Relevance 0.12
Production of recombinant mouse PAP was described previously [11].


Gene_expression (Production) of PAP
8) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0.25
To determine if Atf4 KO pancreata exhibit an inflammatory response similar to exPKO mice, the expression of Reg2, Pap, and Mac-2 mRNAs was quantified.
Gene_expression (expression) of Pap associated with inflammatory response
9) Confidence 0.58 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.55 Pain Relevance 0.05
Primary fallopian tubal transitional cell carcinoma with exfoliation of malignant cells in cervical Pap smear


Gene_expression (smear) of Pap associated with malignant neoplastic disease and transitional cell carcinoma
10) Confidence 0.57 Published 2005 Journal Cytojournal Section Title Doc Link PMC1325042 Disease Relevance 0.20 Pain Relevance 0
The secretory isoforms of human, bovine and mouse PAP are ?
Gene_expression (isoforms) of PAP
11) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.41 Pain Relevance 0.79
Thus, through catalytic restriction, PAP may produce sufficient amounts of adenosine to mediate antinociception but not enough adenosine to cause overt motor side-effects.
Gene_expression (produce) of PAP associated with antinociception and adenocard
12) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.38 Pain Relevance 0.92
Since this AMP concentration is below Km, PAP could produce linear increases in adenosine as the extracellular AMP concentration increases.
Gene_expression (produce) of PAP associated with adenocard
13) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.48 Pain Relevance 0.82
This could be due to the fact that, as an enzyme, the amount of adenosine produced by PAP is limited by substrate concentration.
Gene_expression (produced) of PAP associated with adenocard
14) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.39 Pain Relevance 0.94
As part of our previous study, we used antibodies generated against the secretory isoform of human PAP to detect PAP in mouse DRG neurons and axon terminals in spinal cord [17].
Gene_expression (detect) of PAP in neurons associated with spinal cord
15) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.08 Pain Relevance 0.16
This similarity suggested that some of the antibodies raised against hPAP might detect PAP in rodent tissues.
Gene_expression (detect) of PAP
16) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.09 Pain Relevance 0.11
were largely non-overlapping, there was significant overlap between PAP+ axon terminals and PKC?
Gene_expression (overlap) of PAP
17) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.05 Pain Relevance 0.14
However, this antibody did not recognize PAP in rat DRG neurons or spinal axon terminals (data not shown).
Gene_expression (neurons) of PAP in spinal
18) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.07 Pain Relevance 0.06
Although PAP is found in peptidergic and nonpeptidergic neurons of mice and rats, the percentage of PAP+ neurons that express these markers differs between species.
Gene_expression (found) of PAP in neurons
19) Confidence 0.52 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2800773 Disease Relevance 0.22 Pain Relevance 0.17
Taken together, our studies indicate that PAP is found in peptidergic and nonpeptidergic neurons of the rat, although the extent of co-localization (both in DRG neurons and dorsal spinal cord) differs with species.
Gene_expression (found) of PAP in dorsal associated with spinal cord
20) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.06 Pain Relevance 0.18

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