INT20612

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Context Info
Confidence 0.68
First Reported 1981
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 36
Total Number 37
Disease Relevance 24.35
Pain Relevance 6.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pulmonary artery 4
lungs 2
heart 2
P19 1
macrophage 1
Asap1 (Mus musculus)
Pain Link Frequency Relevance Heat
drug abuse 2 99.90 Very High Very High Very High
anesthesia 25 98.70 Very High Very High Very High
cva 17 98.02 Very High Very High Very High
Migraine 1 97.96 Very High Very High Very High
noradrenaline 1 97.76 Very High Very High Very High
Thoracotomy 2 95.20 Very High Very High Very High
Angina 11 95.16 Very High Very High Very High
Chronic pancreatitis 10 95.16 Very High Very High Very High
backache 3 94.56 High High
adenocard 25 93.36 High High
Disease Link Frequency Relevance Heat
Drug Dependence 2 99.90 Very High Very High Very High
Hypoxia 33 99.86 Very High Very High Very High
Pancreatitis 71 99.84 Very High Very High Very High
Colon Cancer 4 99.76 Very High Very High Very High
Cancer 23 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 40 99.44 Very High Very High Very High
Pressure Volume 2 Under Development 15 99.40 Very High Very High Very High
Hypertension 48 99.36 Very High Very High Very High
Pulmonary Disease 355 99.32 Very High Very High Very High
Pressure And Volume Under Development 28 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAP was not changed in the combined therapy group, but increased in the patients receiving epinephrine alone.
Neg (not) Positive_regulation (increased) of PAP
1) Confidence 0.68 Published 1990 Journal J Cardiothorac Anesth Section Abstract Doc Link 2151889 Disease Relevance 0 Pain Relevance 0.12
Pap was induced in the pancreas of Atf4 KO neonatal mice whereas Mac-2, a macrophage marker, was not induced.
Positive_regulation (induced) of Pap in macrophage
2) Confidence 0.52 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.54 Pain Relevance 0.05
The serum PAP levels were significantly elevated in the patients with gastric, colorectal, biliary tract, hepatocellular, or pancreatic cancers compared with the healthy subjects.
Positive_regulation (elevated) of serum PAP in biliary tract associated with pancreatic cancer
3) Confidence 0.50 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10389686 Disease Relevance 0.87 Pain Relevance 0
The serum PAP levels were also significantly elevated in the patients with acute pancreatitis compared with those in not only the healthy subjects but also the patients with chronic pancreatitis.
Positive_regulation (elevated) of serum PAP associated with pancreatitis and chronic pancreatitis
4) Confidence 0.50 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10389686 Disease Relevance 1.31 Pain Relevance 0.10
These results suggest that the increase of serum PAP levels in patients with gastrointestinal cancers reflects an ectopic expression of PAP in cancer cells and that increased serum levels of PAP in acute pancreatitis are correlated with the disease severity and are prolonged than those of other pancreatic markers.
Positive_regulation (increase) of serum PAP associated with cancer, pancreatitis, gastrointestinal neoplasms and disease
5) Confidence 0.50 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10389686 Disease Relevance 1.45 Pain Relevance 0.09
RESULTS: Before exposure to the anesthetics, PAP increased by 8.6 +/- 1.9 cmH2O for all lungs within 4 min of hypoxia (control PAP for all lungs 19.6 +/- 2.5 cmH2O).
Positive_regulation (increased) of PAP in lungs
6) Confidence 0.42 Published 1995 Journal Anesthesiology Section Body Doc Link 7661356 Disease Relevance 0 Pain Relevance 0
In studies on deacetylation, PAP was generated from APAP both in slices and homogenates of kidneys; acetylated PAH was relatively stable.
Positive_regulation (generated) of PAP
7) Confidence 0.42 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7241376 Disease Relevance 0.07 Pain Relevance 0.22
RESULTS: Before exposure to the anesthetics, PAP increased by 8.6 +/- 1.9 cmH2O for all lungs within 4 min of hypoxia (control PAP for all lungs 19.6 +/- 2.5 cmH2O).
Positive_regulation (increased) of PAP in lungs
8) Confidence 0.39 Published 1995 Journal Anesthesiology Section Body Doc Link 7661356 Disease Relevance 0 Pain Relevance 0
The mean PAP and CI post-induction were 20 +/- 6 mmHg and 2.3 +/- 0.4 L x min(-1) x m(-2), respectively.
Positive_regulation (induction) of PAP
9) Confidence 0.39 Published 2009 Journal Can J Anaesth Section Body Doc Link 19639373 Disease Relevance 0 Pain Relevance 0
HPV, defined as an increase in pulmonary arterial pressure (PAP) at constant flow, was elicited by decreasing inspiratory oxygen concentration from 20% to 3% for 4 min.
Positive_regulation (increase) of PAP
10) Confidence 0.39 Published 1995 Journal Anesthesiology Section Body Doc Link 7661356 Disease Relevance 0 Pain Relevance 0
We did not observe motor paralysis at the highest doses of mouse and human PAP tested, despite the fact that PAP also works via A1R activation (Figs. 5, 6) [3].
Positive_regulation (activation) of PAP associated with paralysis
11) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.36 Pain Relevance 0.95
These results suggest that the increase of serum PAP levels in patients with gastrointestinal cancers reflects an ectopic expression of PAP in cancer cells and that increased serum levels of PAP in acute pancreatitis are correlated with the disease severity and are prolonged than those of other pancreatic markers.
Positive_regulation (increased) of PAP associated with cancer, pancreatitis, gastrointestinal neoplasms and disease
12) Confidence 0.39 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10389686 Disease Relevance 1.35 Pain Relevance 0.08
In a patient who developed PE under enflurane-N2O-O2 anesthesia, neither hypoxemia nor hypotension occurred despite significant increase in PAP.
Positive_regulation (increase) of PAP associated with anesthesia, pressure volume 2 under development and cva
13) Confidence 0.36 Published 1993 Journal Masui Section Abstract Doc Link 8468787 Disease Relevance 0.83 Pain Relevance 0.64
Although mild hypoxemia (SpO2 = 93%) and transient elevation in PAP to 130/80 mmHg (equal to AP) were observed, the biopsy was completed without any major problems.
Positive_regulation (elevation) of PAP
14) Confidence 0.33 Published 2004 Journal Masui Section Abstract Doc Link 15071887 Disease Relevance 0.75 Pain Relevance 0.25
The magnitude of the induction was large; for example, Pap was elevated by 26-fold, and Reg3a and Reg3g were also increased by more than 10-fold at P19.
Positive_regulation (elevated) of Pap in P19
15) Confidence 0.30 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.39 Pain Relevance 0
The data indicate that this depressive effect of NLA on this reflex is weak, and NIC is a potent systemic vasodilator with hyperdynamic hemodynamic effects in addition to an increase in right ventricular function, and PAP was increased.
Positive_regulation (increased) of PAP associated with depression
16) Confidence 0.28 Published 1997 Journal Masui Section Abstract Doc Link 9028093 Disease Relevance 0.32 Pain Relevance 0.19
In acute superimposed hypoxia, HLNB reached higher PAP and femoral vascular resistance than LLNB.
Positive_regulation (reached) of PAP associated with hypoxia
17) Confidence 0.25 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17322112 Disease Relevance 0.67 Pain Relevance 0.12
In 3 patients with pulmonary artery catheter in place, pulmonary arterial pressure (PAP) increased significantly during the embolic events.
Positive_regulation (increased) of PAP in pulmonary artery associated with embolism
18) Confidence 0.24 Published 1993 Journal Masui Section Abstract Doc Link 8468787 Disease Relevance 0.80 Pain Relevance 0.55
In conclusion, we found that PAP was metabolized in hepatocytes predominantly to PAP-GSH conjugates and PAP-N-acetylcysteine conjugates in sufficient quantities to account for the nephrotoxicity of PAP.
Positive_regulation (metabolized) of PAP in hepatocytes associated with nephrotoxicity
19) Confidence 0.20 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10901695 Disease Relevance 0.09 Pain Relevance 0.36
A progressive elevation of pulmonary artery pressure (PAP) was noted after the commencement of right unilateral ventilation.
Positive_regulation (elevation) of PAP in pulmonary artery
20) Confidence 0.19 Published 2002 Journal Chest Section Abstract Doc Link 12226054 Disease Relevance 0.17 Pain Relevance 0.18

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