INT206136

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 4.30
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
Anatomy Link Frequency
nucleus 8
myocardium 2
Th17 cell 2
astrocytes 2
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 156 98.76 Very High Very High Very High
Inflammation 178 95.88 Very High Very High Very High
Inflammatory response 21 91.28 High High
dexamethasone 14 83.52 Quite High
Inflammatory mediators 8 78.24 Quite High
Crohn's disease 96 73.08 Quite High
Acupuncture 6 56.32 Quite High
agonist 45 50.00 Quite Low
anesthesia 18 45.44 Quite Low
fibrosis 7 32.80 Quite Low
Disease Link Frequency Relevance Heat
Cancer 329 99.84 Very High Very High Very High
Glioma 102 96.66 Very High Very High Very High
INFLAMMATION 210 95.88 Very High Very High Very High
Inflammatory Bowel Disease 108 93.52 High High
Hypoxia 5 93.40 High High
Thrombosis 3 90.76 High High
Coagulation Disorder 4 88.92 High High
Acute-phase Reaction 7 88.40 High High
Disease 165 73.08 Quite High
Squamous Cell Neoplasms 6 64.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, our studies indicate that the tyrosine phosphorylation of STAT3 in 48 h PO myocardium does not appear to be required for the increased level of STAT3 in the nucleus, since the distribution of STAT3 or P-STAT3 between cytoplasm and nucleus was not significantly altered in 48 h PO myocardium.
Positive_regulation (increased) of Gene_expression (level) of STAT3 in nucleus
1) Confidence 0.46 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.18 Pain Relevance 0.08
Our present studies indicate a novel mechanism of activation and redistribution of STAT3 in PO myocardium with the involvement of integrin-mediated BMX activation.


Positive_regulation (mediated) of Gene_expression (activation) of STAT3 in myocardium
2) Confidence 0.46 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.06
In 48 RVPO cats, the levels of STAT3 and P-STAT3 in normally loaded LV control were similar to sham control cats, but the RV exhibited a substantial increase in STAT3 levels in both cytoplasmic and nuclear fractions.
Positive_regulation (increase) of Gene_expression (levels) of STAT3
3) Confidence 0.46 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
However, our studies indicate that the tyrosine phosphorylation of STAT3 in 48 h PO myocardium does not appear to be required for the increased level of STAT3 in the nucleus, since the distribution of STAT3 or P-STAT3 between cytoplasm and nucleus was not significantly altered in 48 h PO myocardium.
Positive_regulation (required) of Gene_expression (distribution) of STAT3 in nucleus
4) Confidence 0.46 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.18 Pain Relevance 0.08
However, our studies indicate that the tyrosine phosphorylation of STAT3 in 48 h PO myocardium does not appear to be required for the increased level of STAT3 in the nucleus, since the distribution of STAT3 or P-STAT3 between cytoplasm and nucleus was not significantly altered in 48 h PO myocardium.
Positive_regulation (required) of Gene_expression (level) of STAT3 in nucleus
5) Confidence 0.46 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.18 Pain Relevance 0.08
The overall trend is supportive of a malignant glioma diagnosis playing a more meaningful role compared to steroids in elevated p-STAT-3 levels in this study; however, patients with other types of malignancies also have elevated PBMC p-STAT-3 expression [26] and the PBMC p-STAT-3 levels may be elevated in other medical conditions.
Positive_regulation (elevated) of Gene_expression (expression) of PBMC p-STAT-3 associated with glioma
6) Confidence 0.46 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.39 Pain Relevance 0.08
The signal transducer and activator of transcription 3 (STAT-3) is frequently overexpressed in cancer cells, propagates tumorigenesis, and is a key regulator of immune suppression in cancer patients.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of STAT-3 associated with cancer
7) Confidence 0.46 Published 2009 Journal J Transl Med Section Abstract Doc Link PMC2777138 Disease Relevance 0.58 Pain Relevance 0
The increased expression of STAT3 responsive genes and expression of IL-6 within SCs demonstrate that IL-6/STAT3 signaling occurred in SCs, correlating with an increase in SC proliferation, evidenced by increased Pax7+/PCNA+ cell number in the early stages of the time-course.
Positive_regulation (increased) of Gene_expression (expression) of STAT3
8) Confidence 0.44 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0.03
However, upon RGD stimulation in this 3D model, STAT3 was recruited to the insoluble pellet fraction and P-STAT3 levels were increased both in the insoluble and soluble fractions (p<0.05).
Positive_regulation (increased) of Gene_expression (levels) of STAT3
9) Confidence 0.40 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
However, many factors have been identified that induce p-STAT-3 expression, including growth factors and cytokines, such as IL-6 [44], elaborated by reactive astrocytes [45], epidermal growth factor [43], and Janus kinase 2 [46], and it is uncertain which of these, either individually or in combination, is the etiological agent for inducing p-STAT-3 in PBMC.
Positive_regulation (induce) of Gene_expression (expression) of STAT-3 in astrocytes associated with cytokine
10) Confidence 0.40 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.54 Pain Relevance 0.08
The expression of constitutively active RhoG, Cdc42, and RhoA caused the translocation from the cytoplasm to the nucleus of cotransfected STAT3-GFP.
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of STAT3-GFP in nucleus
11) Confidence 0.29 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.06 Pain Relevance 0.04
Activation of the Jak/Stat3 pathway by IL-6 through its high affinity receptor, IL-6R?
Positive_regulation (Activation) of Gene_expression (/) of Stat3
12) Confidence 0.29 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.88 Pain Relevance 0.05
The associated increased ileal expression of the downstream signaling molecule STAT3 supports this assumption.
Positive_regulation (increased) of Gene_expression (expression) of STAT3
13) Confidence 0.27 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.08 Pain Relevance 0.21
Although increased expression of IL17A, IL17F, IL21 and IL26 was detected in inflamed ileal samples, expression of the indispensable Th17 cell differentiation factors TGFB1 and IL23A, the signaling molecule STAT3 and the Th17 recruitment factors CCR6 and CCL20 were unchanged.


Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of STAT3 in Th17 cell
14) Confidence 0.27 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC3016394 Disease Relevance 0.81 Pain Relevance 0.32
In one study, Rat VSMC were stimulated with IL-6 in the presence or absence of a JAK 2 inhibitor, and the activation of STAT 3 (by Western), MCP-1 (by ELISA) and DNA synthesis (by (3)H-thymidine incorporation) was determined.
Positive_regulation (activation) of Gene_expression (synthesis) of STAT 3
15) Confidence 0.19 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.36 Pain Relevance 0

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