INT206139

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 9.10
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT20) cytoplasm (KRT20)
Anatomy Link Frequency
intestinal epithelium 1
KRT20 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 80 98.60 Very High Very High Very High
Neurotransmitter 12 94.36 High High
Serotonin 4 93.32 High High
cytokine 30 77.04 Quite High
antagonist 14 71.12 Quite High
Hippocampus 8 71.04 Quite High
ischemia 1 62.80 Quite High
chemokine 3 48.08 Quite Low
transdermal 28 5.00 Very Low Very Low Very Low
tolerance 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 143 99.64 Very High Very High Very High
Apoptosis 42 98.72 Very High Very High Very High
INFLAMMATION 93 98.60 Very High Very High Very High
Cold Sores 87 98.28 Very High Very High Very High
Infection 30 98.04 Very High Very High Very High
Amyloid Plaque 47 97.88 Very High Very High Very High
Injury 18 97.88 Very High Very High Very High
Stress 19 96.72 Very High Very High Very High
Disease 677 96.60 Very High Very High Very High
Herpes Simplex Virus 42 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mouse small intestinal epithelium, K20 phosphorylation on serine 13 is induced during apoptosis and tissue injury and thus may serve as stress marker (Zhou et al. 2006).
Phosphorylation (phosphorylation) of K20 in intestinal epithelium associated with stress, injury and apoptosis
1) Confidence 0.48 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.61 Pain Relevance 0
The main alternate hypothesis to the amyloid cascade lends a central role to hyperphosphorylation of the protein tau.
Phosphorylation (hyperphosphorylation) of protein associated with alzheimer's dementia
2) Confidence 0.01 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866463 Disease Relevance 1.13 Pain Relevance 0.13
leads to several secondary events including hyperphosphorylation of the protein tau and generation of neurofibrillary tangles, inflammation, oxidation, and excitotoxicity [60, 84, 86].
Phosphorylation (hyperphosphorylation) of protein associated with inflammation
3) Confidence 0.01 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866463 Disease Relevance 1.48 Pain Relevance 0.13
Presently, the two main competing hypotheses are the amyloid-cascade hypothesis and the hyperphosphorylation of protein tau hypothesis, which are ardently supported by the so-called “baptists” and “tauists” respectively [92].
Phosphorylation (hyperphosphorylation) of protein associated with alzheimer's dementia
4) Confidence 0.01 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866463 Disease Relevance 1.36 Pain Relevance 0.07
Secondary events in this “amyloid cascade” include hyperphosphorylation of the protein tau into neurofibrillary tangles, inflammation, oxidation, and excitotoxicity that eventually cause activation of apoptotis, cell death and neurotransmitter deficits.
Phosphorylation (hyperphosphorylation) of protein associated with neurotransmitter, inflammation, alzheimer's dementia and death
5) Confidence 0.01 Published 2010 Journal Current Neuropharmacology Section Abstract Doc Link PMC2866463 Disease Relevance 1.33 Pain Relevance 0.13
Several of these are known to phosphorylate the microtubule protein tau, an effect that is observed following HSV-1 infection [5].
Phosphorylation (phosphorylate) of protein associated with cold sores and infection
6) Confidence 0.01 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3018626 Disease Relevance 0.75 Pain Relevance 0.04
Protein kinases phosphorylating the microtubule protein tau were identified from the Kinasource database at http://www.kinasource.co.uk/Database/welcomePage.php and from the material available at the ENTREZ gene interaction section for tau (MAPT).
Phosphorylation (phosphorylating) of protein
7) Confidence 0.01 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3018626 Disease Relevance 0.46 Pain Relevance 0
Protein kinases phosphorylating the microtubule protein tau were identified from the Kinasource database at http://www.kinasource.co.uk/Database/welcomePage.php and from the material available at the ENTREZ gene interaction section for tau (MAPT).
Phosphorylation (phosphorylating) of Protein
8) Confidence 0.01 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3018626 Disease Relevance 0.51 Pain Relevance 0
B involves phosphorylation of its inhibitor protein I?
Phosphorylation (phosphorylation) of protein
9) Confidence 0.01 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.48 Pain Relevance 0.17
This lipid molecule is an important second messenger that regulates the phosphorylation of a protein termed AKT, also known as protein kinase B.
Phosphorylation (phosphorylation) of protein
10) Confidence 0.01 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.99 Pain Relevance 0

General Comments

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