INT206142

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.09
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1)
nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)
Anatomy Link Frequency
nucleus 3
STAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 32 100.00 Very High Very High Very High
Inflammation 56 87.68 High High
antagonist 11 55.64 Quite High
chemokine 5 48.68 Quite Low
imagery 1 23.28 Low Low
Pain 5 12.40 Low Low
Somatostatin 22 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Dopamine 9 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 53 91.68 High High
Cancer 187 89.60 High High
Disease 52 89.36 High High
Atherosclerosis 44 88.00 High High
INFLAMMATION 70 87.68 High High
Necrosis 5 87.04 High High
Repression 8 82.40 Quite High
Leiomyosarcoma 59 80.56 Quite High
Hepatitis C Virus Infection 32 77.12 Quite High
Diabetes Mellitus 35 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Downstream signalling occurs mainly via the Ras/Raf/MAP kinase pathway, the phosphatidyl-inositol phosphate kinase (PIP Kinase/PI-3K)/AKT pathway, and the JAK/STAT nuclear translocation.
Localization (translocation) of STAT
1) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.16 Pain Relevance 0
Moreover, it has been shown that the acetylation status of STAT1 (signal transducer and activator of transcription) [44], STAT3 [45], as well as NF-kappa B, is related to their degree of activation/deactivation, which affects the cytokine secretion profile [23].
Localization (secretion) of STAT1 associated with cytokine
2) Confidence 0.59 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.69 Pain Relevance 0.09
Moreover, it has been shown that the acetylation status of STAT1 (signal transducer and activator of transcription) [44], STAT3 [45], as well as NF-kappa B, is related to their degree of activation/deactivation, which affects the cytokine secretion profile [23].
Localization (secretion) of signal transducer and activator of transcription associated with cytokine
3) Confidence 0.52 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.69 Pain Relevance 0.09
The phosphorylated STAT1 forms homodimers that translocate to the nucleus and bind GAS (IFN-?
Localization (translocate) of STAT1 in nucleus
4) Confidence 0.47 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.57 Pain Relevance 0
/ribavirin treatments by mechanisms that differ from our proposed model of action that involves methylation of STAT1 as the key event.
Localization (methylation) of STAT1
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975710 Disease Relevance 0.35 Pain Relevance 0
Oxidized LDL (OxLDL) also initiates STAT1 and STAT3 Tyr-phosphorylation and translocation to the nucleus, with a more marked effect for the extensively modified CuLDL.
Localization (translocation) of STAT1 in nucleus
6) Confidence 0.20 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.63 Pain Relevance 0.05
Subsequently, the activated JAK2 phosphorylates the receptor and STATs (signal transducer and activator of transcription), and dimers of the latter are translocated to the nucleus to promote gene transcription (Carter-Su and Smit 1998).
Localization (translocated) of signal transducer and activator of transcription in nucleus
7) Confidence 0.12 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox