INT206143

Context Info Confidence 0.21 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.34 Pain Relevance 0.06

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3) signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)

Anatomy Link Frequency SH2 2 STAT3 (Homo sapiens)

Pain Link Frequency Relevance Heat depression 1 57.36 Arthritis 10 54.44 Inflammation 54 50.00 Inflammatory response 8 13.60 Inflammatory mediators 2 8.56 cytokine 27 5.00 Inflammatory marker 3 5.00 Pain 3 5.00 tolerance 3 5.00 chemokine 3 5.00

Disease Link Frequency Relevance Heat Dementia 8 63.24 Depression 1 57.36 Stress 3 56.80 Osteomyelitis 1 55.52 Osteitis 1 54.84 Arthritis 10 54.44 INFLAMMATION 68 50.00 Aging 21 50.00 Osteoporosis 35 45.96 Hypercalcemia 11 45.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The important participants in the Interleukin-6 signaling pathway include the Janus kinases (JAKs) Jak1, Jak2 and Tyk2, the signal transducers and activators of transcription STAT1 and STAT3, the tyrosine phosphatase SHP2 [SH2 (Src homology 2) domain-containing tyrosine phosphatase] and transcription factor NF-?

Positive_regulation (activators) of Transcription (transcription) of STAT3 in SH2

1) Confidence 0.21 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.34 Pain Relevance 0.06

General Comments

This test has worked.