INT206144

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 1.77
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK1) cytoskeleton (JAK1) nucleus (JAK1)
cytoplasm (JAK1)
Anatomy Link Frequency
blood 1
monocyte 1
T cell 1
JAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 123 99.78 Very High Very High Very High
Kinase C 1 99.56 Very High Very High Very High
Potency 86 99.36 Very High Very High Very High
agonist 68 95.92 Very High Very High Very High
antagonist 11 66.88 Quite High
rheumatoid arthritis 68 65.52 Quite High
Arthritis 154 63.24 Quite High
fibrosis 1 62.08 Quite High
Inflammation 124 50.00 Quite Low
diabetic neuropathy 1 30.08 Quite Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 6 96.60 Very High Very High Very High
Stress 30 93.72 High High
Leiomyosarcoma 59 91.76 High High
Aging 26 79.68 Quite High
Diabetes Mellitus 49 79.24 Quite High
Teratoma 2 76.92 Quite High
Severe Combined Immunodeficiency 1 72.72 Quite High
Disease Progression 6 69.84 Quite High
Adenocarcinoma 2 69.40 Quite High
Disease 80 66.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
to the type II IFN receptor, JAK1 and JAK2 are activated and phosphorylate the signal transducer and activator of transcription 1(STAT1) on the tyrosine residue at position 701 (Tyr701) and the serine residue at position 727 (Ser727) (Parmar and Platanias, 2005; Platanias, 2005) (Fig. 2).
Phosphorylation (phosphorylate) of JAK1
1) Confidence 0.57 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.56 Pain Relevance 0
Small GTPases of the Ras protein superfamily stimulate the tyrosine phosphorylation and activation of the JAK family of intracellular kinases.
Phosphorylation (phosphorylation) of JAK
2) Confidence 0.31 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.10 Pain Relevance 0
Inhibition of JAK-dependent STAT phosphorylation in whole blood was also examined as a measure of JAK potency and selectivity.
Phosphorylation (phosphorylation) of JAK-dependent in blood associated with potency
3) Confidence 0.04 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.18 Pain Relevance 0.37
Normal human, mouse or rat whole blood pre-treated with CP-690,550 was stimulated with cytokines, and STAT phosphorylation downstream of receptor-associated JAK activation was monitored in monocyte and T cell populations as summarized in Table 1.
Phosphorylation (phosphorylation) of JAK in T cell associated with cytokine
4) Confidence 0.04 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.38
AGE receptor binding can initiate important signalling pathways involving activation of protein kinase C [108, 165], tyrosine phosphorylation of Janus kinase (JAK)/signal transducers and activators of transcription (STAT) [66], recruitment of phosphotidylinositol 3' kinase to Ras, [30] and induction of oxidative stress cascades which lead toNF?
Phosphorylation (phosphorylation) of Janus kinase associated with stress and kinase c
5) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.70 Pain Relevance 0.11
Representative ES cells growth activating signal mediators, JAK/STAT3 and ERK1/2 phosphorylation was clearly upregulated at 12 hours (P<0.05) after exogenic Oct4 expression.
Phosphorylation (phosphorylation) of JAK
6) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.22 Pain Relevance 0.03
Normal human, mouse or rat whole blood pre-treated with CP-690,550 was stimulated with cytokines, and STAT phosphorylation downstream of receptor-associated JAK activation was monitored in monocyte and T cell populations as summarized in Table 1.
Phosphorylation (phosphorylation) of JAK in monocyte associated with cytokine
7) Confidence 0.01 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.38
JAK/STAT pathway by inhibiting the phosphorylation of specific JAK and STAT
Phosphorylation (phosphorylation) of JAK
8) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0 Pain Relevance 0.37

General Comments

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