INT206148

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.72
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1)
nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)
Anatomy Link Frequency
SH2 2
STAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 2 57.36 Quite High
Arthritis 10 54.44 Quite High
Inflammation 54 50.00 Quite Low
Inflammatory response 8 12.80 Low Low
Inflammatory mediators 2 7.76 Low Low
cytokine 27 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 32 97.20 Very High Very High Very High
Targeted Disruption 2 91.16 High High
Dementia 8 63.24 Quite High
Depression 2 57.36 Quite High
Stress 3 56.80 Quite High
Osteomyelitis 1 55.52 Quite High
Osteitis 1 54.84 Quite High
Arthritis 10 54.44 Quite High
INFLAMMATION 68 50.00 Quite Low
Aging 21 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
induced transcription factor STAT1 and its binding to DNA response elements, thereby increasing the induction of ISGs and enhancing the inhibitory effect of IFN?
Positive_regulation (induced) of Transcription (transcription) of STAT1
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975710 Disease Relevance 0.37 Pain Relevance 0
The important participants in the Interleukin-6 signaling pathway include the Janus kinases (JAKs) Jak1, Jak2 and Tyk2, the signal transducers and activators of transcription STAT1 and STAT3, the tyrosine phosphatase SHP2 [SH2 (Src homology 2) domain-containing tyrosine phosphatase] and transcription factor NF-?
Positive_regulation (activators) of Transcription (transcription) of STAT1 in SH2
2) Confidence 0.15 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.34 Pain Relevance 0.06

General Comments

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