INT206151

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.35
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6ST) extracellular region (IL6ST) plasma membrane (IL6ST)
Anatomy Link Frequency
smooth muscle cells 2
endometrium 2
IL6ST (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 37 63.44 Quite High
Inflammation 54 50.00 Quite Low
metalloproteinase 6 7.60 Low Low
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 44 96.68 Very High Very High Very High
Disorder Of Lipid Metabolism 6 72.92 Quite High
Hyperplasia 3 58.56 Quite High
INFLAMMATION 68 50.00 Quite Low
Aging 21 50.00 Quite Low
Down Syndrome 2 18.76 Low Low
Osteoporosis 35 5.00 Very Low Very Low Very Low
Diabetes Mellitus 33 5.00 Very Low Very Low Very Low
Cardiovascular Disease 20 5.00 Very Low Very Low Very Low
Disease 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, we have shown that both IL-11 and GP130 mRNA expression are elevated in the late secretory phase of the menstrual cycle whereas IL-11R?
Positive_regulation (elevated) of Gene_expression (expression) of GP130 mRNA
1) Confidence 0.24 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.06
GP130 mRNA expression was significantly elevated in the mid-late secretory phase compared with the proliferative phase of the menstrual cycle (Fig. 3E; P < 0.005; P < 0.05 respectively) but showed no significant change between first trimester decidua and pooled samples of non-pregnant endometrium (Fig. 3F).
Positive_regulation (elevated) of Gene_expression (expression) of GP130 mRNA in endometrium
2) Confidence 0.23 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
E-LDL accumulates in human vascular smooth muscle cells (VSMC), where it stimulates the expression of gp130, the signal-transducing chain of the IL-6 receptor (IL-6R) family, and the secretion of Interleukin-6 [83].
Positive_regulation (stimulates) of Gene_expression (expression) of gp130 in smooth muscle cells
3) Confidence 0.13 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.35 Pain Relevance 0

General Comments

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