INT206158

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.44
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CDC42EP1) plasma membrane (CDC42EP1) cytoplasm (CDC42EP1)
Anatomy Link Frequency
endothelial cell 1
CDC42EP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 94.64 High High
cytokine 105 91.56 High High
Inflammation 98 50.00 Quite Low
metalloproteinase 104 5.00 Very Low Very Low Very Low
COX-2 inhibitor 23 5.00 Very Low Very Low Very Low
chemokine 23 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 53 99.92 Very High Very High Very High
Herpes Simplex Virus 238 99.76 Very High Very High Very High
Infection 131 99.36 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 97 93.64 High High
Cancer 38 85.68 High High
Apoptosis 16 80.64 Quite High
Cardiovascular Disease 22 80.00 Quite High
Malignant Neoplastic Disease 6 79.36 Quite High
Disease 30 72.40 Quite High
INFLAMMATION 117 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, some evidence suggests that statins alter the intracellular signals dependent on Rho GTPases [16], the functional activity of LFA-1/ICAM-1 adhesion molecules [17], the expression of the CCR5 coreceptor and the secretion of RANTES [18], and may exert significant modulatory effects on the balance of the cytokine network in human beings [19,20].
Regulation (dependent) of GTPases associated with adhesions and cytokine
1) Confidence 0.01 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.64 Pain Relevance 0.05
Collectively, these results clearly demonstrated that KSHV induced COX-2/PGE2 in the infected cell microenvironment plays an important role in endothelial cell adhesion by modulating the activity of Rac1-GTPases.


Regulation (modulating) of GTPases in endothelial cell associated with herpes simplex virus and adhesions
2) Confidence 0.00 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.72 Pain Relevance 0.09
IL-6 itself may produce a delayed phosphorylation and activation of STAT3, and the JAK/STAT3 pathway is an indirect target of Ras and Rho GTPases [70].
Regulation (target) of GTPases
3) Confidence 0.00 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.08 Pain Relevance 0

General Comments

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