INT206159

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.38
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 65 84.40 Quite High
alcohol 3 71.04 Quite High
Inflammatory marker 3 61.92 Quite High
ischemia 3 55.36 Quite High
Morphine 3 28.72 Quite Low
tolerance 3 10.44 Low Low
cytokine 29 5.00 Very Low Very Low Very Low
antagonist 16 5.00 Very Low Very Low Very Low
adenocard 13 5.00 Very Low Very Low Very Low
Arthritis 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 35 98.80 Very High Very High Very High
Diabetes Mellitus 41 85.24 High High
INFLAMMATION 79 84.40 Quite High
Hypoxia 11 83.72 Quite High
Metabolic Syndrome 43 83.24 Quite High
Obesity 25 78.32 Quite High
Overweight 1 78.08 Quite High
Pressure And Volume Under Development 6 76.24 Quite High
Hyperplasia 4 72.48 Quite High
Nicotine Addiction 4 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar to our results in Figures 4 and 5, we observed that silencing (siRNA) of mTOR, Akt, Src, Rictor or inhibition of PI3 kinase activity significantly attenuated VEGF-induced human EC proliferation (Figure 6-A) and migration (Figure 6-B) with Src silencing inducing the greatest inhibition of these activites.
Negative_regulation (attenuated) of Regulation (proliferation) of VEGF-induced
1) Confidence 0.24 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0
VEGF up-regulation was abrogated by caffeine.
Negative_regulation (abrogated) of Regulation (regulation) of VEGF
2) Confidence 0.12 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 1.44 Pain Relevance 0.10
Furthermore, incadronate disodium significantly prevented transcriptional activation of nuclear factor-kappaB and activator protein-1 and the subsequent up-regulation of VEGF mRNA levels in AGE-exposed EC.
Negative_regulation (prevented) of Regulation (regulation) of VEGF mRNA
3) Confidence 0.12 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.94 Pain Relevance 0.11

General Comments

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