INT206166

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.13
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 44 93.76 High High
Inflammation 79 88.48 High High
cytokine 38 88.24 High High
withdrawal 2 72.12 Quite High
dexamethasone 4 30.24 Quite Low
imagery 3 13.56 Low Low
antagonist 2 12.64 Low Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 166 95.88 Very High Very High Very High
Atherosclerosis 44 88.80 High High
INFLAMMATION 96 88.48 High High
Multiple Myeloma 61 82.64 Quite High
Necrosis 5 77.32 Quite High
Diabetes Mellitus 40 67.16 Quite High
Repression 6 62.80 Quite High
Hematologic Neoplasms 39 50.00 Quite Low
Aging 22 50.00 Quite Low
Osteoporosis 35 48.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SOCS3 can bind phosphotyrosines on the JAK2 receptors, physically blocking STAT3 binding, as well as biding to JAK2, directly blocking JAK kinase activity [50].
Negative_regulation (blocking) of STAT3 Binding (binding) of
1) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0.07
By 1 wk RVPO, both STAT3 recruitment and phosphorylation were substantially reduced.
Negative_regulation (reduced) of STAT3 Binding (recruitment) of
2) Confidence 0.40 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
Wang and colleagues [211] showed that 15d-PGJ2 and troglitazone significantly inhibited Stat3 binding to its cognate response element and inhibited Stat3 binding to the promoters of c-MYC and MCL-1 thereby preventing transactivation of these Stat3 target genes.
Negative_regulation (inhibited) of Stat3 Binding (binding) of
3) Confidence 0.25 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.60 Pain Relevance 0.09
In one study, Genistein, a nonspecific Tyr-kinase inhibitor, and AG490, a specific inhibitor of JAKs, markedly prevented the CuLDL-induced enhancement of STAT1 and STAT3 Tyr-phosphorylation and DNA-binding activity, suggesting that JAKs are the main kinases involved in STATs' activation by oxidized LDL [125].
Negative_regulation (prevented) of STAT3 Binding (binding) of
4) Confidence 0.18 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.53 Pain Relevance 0.04

General Comments

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