INT206181

Context Info Confidence 0.00 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.40 Pain Relevance 0

cytosol (FDPS) mitochondrion (FDPS) small molecule metabolic process (FDPS) nucleolus (FDPS) nucleus (FDPS) cytoplasm (FDPS)

FDPS (Homo sapiens) ras (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 54 50.00 cytokine 27 36.88 metalloproteinase 2 7.28 Arthritis 10 5.00 Inflammatory response 8 5.00 Inflammatory marker 3 5.00 Pain 3 5.00 tolerance 3 5.00 chemokine 3 5.00 alcohol 2 5.00

Disease Link Frequency Relevance Heat Myeloid Leukemia 2 97.76 Leukemia 2 79.12 Apoptosis 8 75.92 Cancer 18 70.24 INFLAMMATION 68 50.00 Aging 21 50.00 Atherosclerosis 44 5.00 Osteoporosis 35 5.00 Diabetes Mellitus 33 5.00 Cardiovascular Disease 20 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In summary, isoprenoids farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GPP) are necessary for posttranslational lipid modification (prenylation) and, hence, the function of Ras and other small GTPase proteins such as Ras, Rho, Rac, and Rab [52].

FPP Positive_regulation (necessary) of Ras

1) Confidence 0.00 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.40 Pain Relevance 0

General Comments

This test has worked.