INT206198

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESRRG) nucleus (ESRRG)
Anatomy Link Frequency
lung 4
ESRRG (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 6 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 36 100.00 Very High Very High Very High
Lung Cancer 96 99.84 Very High Very High Very High
Second Primary Neoplasms 246 99.06 Very High Very High Very High
Cancer 132 96.64 Very High Very High Very High
Lymphatic System Cancer 174 96.56 Very High Very High Very High
Death 12 95.72 Very High Very High Very High
Nicotine Addiction 12 87.40 High High
Metastasis 12 74.24 Quite High
Malignant Neoplastic Disease 42 65.44 Quite High
Hyperplasia 6 64.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transition from mantle to 35 Gy IFRT was associated with a 67% and 36% reduction in estimated ERR of lung cancer in the selected female and male case, respectively.
Negative_regulation (reduction) of ERR in lung associated with lung cancer
1) Confidence 0.18 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1847517 Disease Relevance 1.23 Pain Relevance 0
In addition, ERR estimates were based on only three cases, and although these cases were selected to be representative of the mean dose delivered to breast and lung with 35 Gy mantle RT, the broad distribution of ERR reductions that might be expected in a large population of patients has probably been under-sampled.
Negative_regulation (reductions) of ERR in lung
2) Confidence 0.15 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1847517 Disease Relevance 0.64 Pain Relevance 0
We have used a dosimetric risk-modeling approach to second-cancer risk estimation: compared to mantle RT, we have measured the reduction in dose to relevant normal tissues associated with modern IFRT, and then modeled the associated reductions in ERR for radiation-induced breast and lung cancer.
Negative_regulation (reductions) of ERR in lung associated with lung cancer and cancer
3) Confidence 0.13 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1847517 Disease Relevance 0.95 Pain Relevance 0
Younger patients were predicted to have higher ERRs for SC than older patients, but similar proportional reductions in the ERR.
Negative_regulation (reductions) of ERR associated with second primary neoplasms
4) Confidence 0.13 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1847517 Disease Relevance 0.85 Pain Relevance 0
Moving from 35 Gy mantle RT to 35 Gy IFRT reduces predicted ERR for female breast and lung cancer by approximately 65%, and for male lung cancer by approximately 35%; moving from 35 Gy IFRT to 20 Gy IFRT reduces predicted ERRs approximately 40% more.
Negative_regulation (reduces) of ERR in lung associated with lung cancer
5) Confidence 0.13 Published 2007 Journal Radiat Oncol Section Abstract Doc Link PMC1847517 Disease Relevance 1.21 Pain Relevance 0
The reduction in radiation dose and SC risk associated with the transition to IFRT was most evident for the female breast, where the estimated ERR for radiation-induced breast cancer decreased by 64%.
Negative_regulation (decreased) of ERR associated with second primary neoplasms and breast cancer
6) Confidence 0.13 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1847517 Disease Relevance 1.33 Pain Relevance 0

General Comments

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