INT20622

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Context Info
Confidence 0.76
First Reported 1990
Last Reported 2010
Negated 4
Speculated 6
Reported most in Abstract
Documents 107
Total Number 115
Disease Relevance 77.97
Pain Relevance 16.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LDHA) small molecule metabolic process (LDHA) oxidoreductase activity (LDHA)
cytoplasm (LDHA)
Anatomy Link Frequency
liver 7
muscle 5
blood 4
pericardial fluid 4
platelets 3
LDHA (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 439 99.84 Very High Very High Very High
Paracetamol 32 99.84 Very High Very High Very High
methotrexate 5 99.46 Very High Very High Very High
lidocaine 43 99.36 Very High Very High Very High
Pain 115 98.64 Very High Very High Very High
tolerance 8 97.88 Very High Very High Very High
Inflammation 579 97.44 Very High Very High Very High
cytokine 230 97.36 Very High Very High Very High
palliative 41 97.12 Very High Very High Very High
abdominal pain 32 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 741 100.00 Very High Very High Very High
Cirrhosis 281 100.00 Very High Very High Very High
Necrosis 165 100.00 Very High Very High Very High
Chronic Hepatitis 124 100.00 Very High Very High Very High
Anaemia 44 100.00 Very High Very High Very High
Hemolytic Anemia 22 100.00 Very High Very High Very High
Thrombocytopenia 16 100.00 Very High Very High Very High
Malignant Pleural Effusion 4 99.98 Very High Very High Very High
Myalgia 59 99.94 Very High Very High Very High
Hypoalbuminemia 20 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The serum levels of alpha-fetoprotein, human chorionic gonadotropin-beta, and lactate dehydrogenase (LDH) were not elevated.
Gene_expression (levels) of LDH
1) Confidence 0.76 Published 2010 Journal Hinyokika Kiyo Section Abstract Doc Link 20104012 Disease Relevance 0.86 Pain Relevance 0.10
The serum levels of alpha-fetoprotein, human chorionic gonadotropin-beta, and lactate dehydrogenase (LDH) were not elevated.
Gene_expression (levels) of lactate dehydrogenase
2) Confidence 0.76 Published 2010 Journal Hinyokika Kiyo Section Abstract Doc Link 20104012 Disease Relevance 0.85 Pain Relevance 0.10
Muscle soreness (MS), lactate dehydrogenase (LDH) activity, lipid peroxidation, protein carbonylation, tumor necrosis factor-alpha (TNF-alpha), and interleukin 10 (IL-10) levels were determined.
Gene_expression (levels) of LDH in Muscle associated with necrosis, cancer and myalgia
3) Confidence 0.74 Published 2010 Journal J Physiol Sci Section Abstract Doc Link 19859781 Disease Relevance 0.65 Pain Relevance 0.10
The expression of MSIs of CK, GP, PGAM, and LDH was always significantly increased in innervated as compared to noninnervated fibers.
Gene_expression (expression) of LDH
4) Confidence 0.72 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152794 Disease Relevance 0.42 Pain Relevance 0.08
While the expression of MSIs of GP and PGAM was the same in contracting-innervated and paralyzed-innervated muscle fibers, the expression of MSIs of CK and LDH in paralyzed-innervated muscle fibers was very slightly decreased as compared to their contracting-innervated controls.
Gene_expression (expression) of LDH in muscle fibers associated with paralysis
5) Confidence 0.72 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152794 Disease Relevance 0.44 Pain Relevance 0.07
Lactate dehydrogenase activity
Gene_expression (activity) of Lactate
6) Confidence 0.67 Published 2006 Journal Part Fibre Toxicol Section Body Doc Link PMC1459188 Disease Relevance 0 Pain Relevance 0
Dividing ascitic fluid into the transudate and exudate categories, such as is done with malignant pleural effusions using lactate dehydrogenase (LDH), protein and the ratios of these values (serum to ascites) has not proven to be beneficial for malignant ascites.
Gene_expression (using) of LDH associated with malignant neoplastic disease, pressure and volume under development and malignant pleural effusion
7) Confidence 0.65 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880345 Disease Relevance 2.66 Pain Relevance 0.03
In patients that received potential curative therapies LDH >or=2000 U/l, WBC >50 GPT/l, CD34 surface expression on the AML blasts, secondary AML, unfavorable karyotype and no allogeneic HSCT at some point of treatment course were associated with unfavorable prognosis.
Gene_expression (expression) of LDH associated with myeloid leukemia
8) Confidence 0.65 Published 2005 Journal Neoplasma Section Abstract Doc Link 16151585 Disease Relevance 0.82 Pain Relevance 0.10
All patients experience significant anemia, severe thrombocytopenia, increased lactate dehydrogenase, elevated serum creatinine, and oliguria.
Gene_expression (experience) of lactate dehydrogenase associated with anaemia, oliguria and thrombocytopenia
9) Confidence 0.65 Published 1994 Journal Am. J. Hematol. Section Abstract Doc Link 7977300 Disease Relevance 1.75 Pain Relevance 0.10
Our studies demonstrate that in human muscle: (1) total enzymatic activities and the expression of MSIs of GP and PGAM are regulated by neuronal effect(s); (2) total enzymatic activities of CK, LDH, and AChE depend mainly on muscle contractile activity; and (3) MSIs of CK and LDH are regulated predominantly by neuronal factors and to a much lesser degree by muscle contractile activity.
Gene_expression (expression) of LDH in muscle
10) Confidence 0.63 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152794 Disease Relevance 0.40 Pain Relevance 0.06
Laboratory tests showed a slight leukocytosis and thrombocytosis, normal haemoglobin, creatinine and electrolytes levels, a lactate dehydrogenase (LDH) level of 373IU/L that increased to 6969IU/L in eight days, normal alkaline phosphate, normal transaminases and bilirubins.
Gene_expression (levels) of LDH associated with leukocytosis and thrombosis related under development
11) Confidence 0.63 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829594 Disease Relevance 1.36 Pain Relevance 0.12
Laboratory tests showed a slight leukocytosis and thrombocytosis, normal haemoglobin, creatinine and electrolytes levels, a lactate dehydrogenase (LDH) level of 373IU/L that increased to 6969IU/L in eight days, normal alkaline phosphate, normal transaminases and bilirubins.
Gene_expression (levels) of lactate dehydrogenase associated with leukocytosis and thrombosis related under development
12) Confidence 0.63 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829594 Disease Relevance 1.36 Pain Relevance 0.12
The levels of AFP, hCG beta and LDH were normal.
Gene_expression (levels) of LDH
13) Confidence 0.62 Published 2001 Journal Hinyokika Kiyo Section Abstract Doc Link 11496403 Disease Relevance 0.36 Pain Relevance 0.19
Platelet lysis expressed as LDH activity of lysed cells was dose dependent.
Gene_expression (expressed) of LDH in Platelet
14) Confidence 0.60 Published 2007 Journal Toxicon Section Abstract Doc Link 17599379 Disease Relevance 0.57 Pain Relevance 0.24
Levels of CRP, glucose, albumin, total protein, Creatine Kinase (CK), Creatine Kinase-MB (CK-MB), and Lactate Dehydrogenase (LDH) were determined in pericardial fluid samples and in simultaneously collected blood samples from radial artery.
Spec (determined) Gene_expression (Levels) of Lactate Dehydrogenase in radial artery
15) Confidence 0.59 Published 2006 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2688157 Disease Relevance 1.46 Pain Relevance 0.19
Levels of CRP, glucose, albumin, total protein, Creatine Kinase (CK), Creatine Kinase-MB (CK-MB), and Lactate Dehydrogenase (LDH) were determined in pericardial fluid samples and in simultaneously collected blood samples from radial artery.
Spec (determined) Gene_expression (Levels) of LDH in radial artery
16) Confidence 0.59 Published 2006 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2688157 Disease Relevance 1.46 Pain Relevance 0.19
The pericardial CRP and LDH levels in the PMI group were higher than in the SAP (p = 0.015 and p = 0.000, respectively) and USAP (p = 0.011, p = 0.047) groups.
Gene_expression (levels) of LDH associated with stable angina pectoris, cv general 3 under development and myocardial infarction
17) Confidence 0.59 Published 2006 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2688157 Disease Relevance 1.53 Pain Relevance 0.17
She was hypercalcaemic (corrected calcium 3.15 mmol/l, phosphate 1.82 mmol/l, alkaline phosphatase 102 U/l) with deranged liver function (LDH 1085 U/l, AST 46 U/l, normal bilirubin, albumin and globulin levels).
Gene_expression (levels) of LDH in liver
18) Confidence 0.58 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2075505 Disease Relevance 1.22 Pain Relevance 0.15
Culine et al. has shown that LDH levels and PS constitute two major prognostic factors for CUP [6].
Gene_expression (levels) of LDH
19) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715134 Disease Relevance 0.35 Pain Relevance 0
NM improved the viability of the hepatocytes, lowered the levels of LDH, and increased lidocaine clearance and albumin production in a concentration-dependent manner.
Gene_expression (levels) of LDH in hepatocytes associated with lidocaine
20) Confidence 0.58 Published 1999 Journal Cell Transplant Section Abstract Doc Link 10478723 Disease Relevance 0.14 Pain Relevance 0.19

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