INT206239

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD24) signal transducer activity (CD24)
CD24 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 190 79.80 Quite High
Central nervous system 10 49.04 Quite Low
Angina 2 11.00 Low Low
Pain 2 9.32 Low Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 98 95.16 Very High Very High Very High
Multiple Sclerosis 202 79.80 Quite High
Autoimmune Disease 50 67.92 Quite High
Contagious Ecthyma 2 60.48 Quite High
Stroke 2 16.68 Low Low
Interstitial Lung Diseases 2 16.20 Low Low
Hypertension 2 15.12 Low Low
Central Nervous System Vasculitis 2 14.16 Low Low
Nephritis 2 12.76 Low Low
Angina 2 11.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the two alleles were present in the same cells and therefore were transcribed at the same rate, our data demonstrate that the P1527 variant has a strong impact on mRNA expression of CD24 in vivo, most likely by post-transcriptional mechanisms.


Spec (likely) Regulation (impact) of Transcription (expression) of CD24
1) Confidence 0.45 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.11 Pain Relevance 0.03
Two cis elements of mouse Cd24 mRNA, a negative and a positive cis element, regulate the stability of mouse Cd24 mRNA expression and determine cell-surface CD24 expression [31].
Regulation (regulate) of Spec (determine) Transcription (elements) of Cd24
2) Confidence 0.45 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.86 Pain Relevance 0.15

General Comments

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