INT20624

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Context Info
Confidence 0.60
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.49
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNC) extracellular space (TNC) extracellular region (TNC)
cell adhesion (TNC)
Anatomy Link Frequency
shoulder 2
muscle 2
temporomandibular joint 2
fibroblasts 2
connective tissue 2
TNC (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 10 99.84 Very High Very High Very High
carpal tunnel syndrome 5 75.00 Quite High
tetrodotoxin 1 64.40 Quite High
Inflammation 1 25.00 Low Low
palliative 1 5.00 Very Low Very Low Very Low
Ziconotide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 7 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 10 99.84 Very High Very High Very High
Sprains And Strains 1 98.92 Very High Very High Very High
Cancer 2 96.16 Very High Very High Very High
Communicable Diseases 1 95.40 Very High Very High Very High
Myocardial Infarction 1 94.44 High High
Paralysis 5 92.28 High High
Neointima 1 92.20 High High
Disease 7 81.52 Quite High
Carpal Tunnel Syndrome 5 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although tenascin-C expression by synovial lining and connective tissue shows marked regional variation and seems inconsistent, in vitro examination suggested that tenascin-C production by these tissues is regulated in response to mechanical strain on the flexor tenosynovium.
Regulation (regulated) of Gene_expression (production) of tenascin-C in connective tissue associated with sprains and strains
1) Confidence 0.60 Published 2006 Journal Histol. Histopathol. Section Abstract Doc Link 16493581 Disease Relevance 0.73 Pain Relevance 0.34
CONCLUSIONS: These results indicate that hypoxic conditions with inflammation modulate the tenascin-C expression in synovial fibroblasts, but not in disk cells.


Neg (not) Regulation (modulate) of Gene_expression (expression) of tenascin-C in fibroblasts
2) Confidence 0.60 Published 2008 Journal Oral Dis Section Body Doc Link 18173448 Disease Relevance 0.12 Pain Relevance 0
Effect of hypoxia and interleukin-1beta on expression of tenascin-C in temporomandibular joint.
Regulation (Effect) of Gene_expression (expression) of tenascin-C in temporomandibular joint associated with snapping jaw and hypoxia
3) Confidence 0.44 Published 2008 Journal Oral Dis Section Title Doc Link 18173448 Disease Relevance 0.57 Pain Relevance 0.47
Our studies demonstrate that in human muscle: (1) total enzymatic activities and the expression of MSIs of GP and PGAM are regulated by neuronal effect(s); (2) total enzymatic activities of CK, LDH, and AChE depend mainly on muscle contractile activity; and (3) MSIs of CK and LDH are regulated predominantly by neuronal factors and to a much lesser degree by muscle contractile activity.
Regulation (regulated) of Gene_expression (expression) of GP in muscle
4) Confidence 0.04 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152794 Disease Relevance 0.40 Pain Relevance 0.06
Among six patients judged by GPs as showing signs of danger, referral was proposed by GPs in one case only; others received a GP prescription (three prescriptions—the only ones during the study) or TP treatment; two of them had terminal cancer, two had an infectious disease, one heart failure and one unexplained shoulder dysfunction.
Regulation (received) of Gene_expression (prescription) of GP in shoulder associated with cancer, communicable diseases and myocardial infarction
5) Confidence 0.03 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892346 Disease Relevance 0.66 Pain Relevance 0

General Comments

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