INT206244

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.71
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD24) signal transducer activity (CD24)
CD24 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 665 99.52 Very High Very High Very High
Central nervous system 35 92.00 High High
cytokine 9 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Angina 7 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 707 99.52 Very High Very High Very High
Disease Progression 21 99.40 Very High Very High Very High
Systemic Lupus Erythematosus 343 98.96 Very High Very High Very High
Autoimmune Disease 175 98.96 Very High Very High Very High
Disease 58 96.32 Very High Very High Very High
Cancer 70 86.40 High High
Genetic Predisposition To Disease 14 82.00 Quite High
Triploidy 2 68.08 Quite High
Skin Cancer 10 66.12 Quite High
Rhinitis 1 45.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, using data from two independent cohorts of families, we also established a strong association of the CD24 P1527 polymorphism with MS.
CD24 Binding (association) of associated with multiple sclerosis
1) Confidence 0.48 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.75 Pain Relevance 0.25
We designed primers specific for CD24 (forward: 5?
CD24 Binding (specific) of
2) Confidence 0.37 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0 Pain Relevance 0
We examined the association of the CD24 polymorphisms in the 3?
CD24 Spec (examined) Binding (association) of
3) Confidence 0.37 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.50 Pain Relevance 0.25
Third, survival analysis revealed a significant association (even after correcting for multiple tests) of CD24 P1527 with MS disease progression; MS patients with the P1527del allele had a significantly delayed progression.
CD24 Binding (association) of associated with multiple sclerosis and disease progression
4) Confidence 0.37 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.97 Pain Relevance 0.37
We used a Caucasian cohort of age and sex-controlled samples (Table 3) to test the potential association between CD24 polymorphism and risk of SLE.
CD24 Binding (association) of associated with systemic lupus erythematosus
5) Confidence 0.36 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.84 Pain Relevance 0.07
Based on the observed data pattern and the structure of the family cohorts, we have chosen TRANSMIT soft ware to detect association between CD24 polymorphism and risk of autoimmune diseases to maximize the statistical power.
CD24 Binding (association) of associated with autoimmune disease
6) Confidence 0.36 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 1.10 Pain Relevance 0.27
We used cases/control studies to determine the association between CD24 polymorphism and the risk of MS and SLE.
CD24 Binding (association) of associated with multiple sclerosis and systemic lupus erythematosus
7) Confidence 0.36 Published 2007 Journal PLoS Genetics Section Abstract Doc Link PMC1847692 Disease Relevance 1.13 Pain Relevance 0.22
Compared to isotype controls, USC-HN1 displays significantly increased staining of FABP5, E-cadherin, and CD24.
CD24 Binding (staining) of
8) Confidence 0.15 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.42 Pain Relevance 0

General Comments

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