INT20630

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Context Info
Confidence 0.47
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 15.79
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CHKB)
Anatomy Link Frequency
thrombocytes 4
chest 4
muscle cell 2
CHKB (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 21 99.88 Very High Very High Very High
Angina 12 99.10 Very High Very High Very High
Inflammation 14 97.24 Very High Very High Very High
ischemia 28 89.64 High High
abdominal pain 14 87.48 High High
Pain 6 86.96 High High
withdrawal 1 85.12 High High
tetrodotoxin 1 84.20 Quite High
headache 5 67.36 Quite High
pain pelvic 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ectopic Pregnancy 665 100.00 Very High Very High Very High
Necrosis 21 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 3 100.00 Very High Very High Very High
Cv General 3 Under Development 11 99.88 Very High Very High Very High
Myocardial Infarction 58 99.74 Very High Very High Very High
Arrhythmias 2 Under Development 1 99.56 Very High Very High Very High
Angina 12 99.10 Very High Very High Very High
Hypopituitarism 3 98.40 Very High Very High Very High
Paralysis 5 98.20 Very High Very High Very High
Chlamydia Infection 14 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
INVESTIGATIONS: Laboratory results showed elevated levels for bilirubin, CK, BUN, creatinine and low thrombocytes in patients 1 and 2.
Positive_regulation (elevated) of Gene_expression (thrombocytes) of CK in thrombocytes
1) Confidence 0.47 Published 2010 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 20358494 Disease Relevance 0.10 Pain Relevance 0
INVESTIGATIONS: Laboratory results showed elevated levels for bilirubin, CK, BUN, creatinine and low thrombocytes in patients 1 and 2.
Positive_regulation (elevated) of Gene_expression (levels) of CK in thrombocytes
2) Confidence 0.47 Published 2010 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 20358494 Disease Relevance 0.10 Pain Relevance 0
The expression of MSIs of CK, GP, PGAM, and LDH was always significantly increased in innervated as compared to noninnervated fibers.
Positive_regulation (increased) of Gene_expression (expression) of CK
3) Confidence 0.39 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152794 Disease Relevance 0.43 Pain Relevance 0.08
In UA/NSTEMI, the severity of the presenting chest pain, ischemic ST-T changes, post-MI angina, and elevated serum levels of CK-MB and of troponin T or I are markers of risk [1].
Positive_regulation (elevated) of Gene_expression (levels) of CK-MB in chest associated with angina, arrhythmias 2 under development, cva and myocardial infarction
4) Confidence 0.38 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 1.28 Pain Relevance 0.36
His serial cardiac marker assays revealed an elevated total creatine kinase (CK) and 2 negative cardiac troponin levels.
Positive_regulation (elevated) of Neg (negative) Gene_expression (levels) of CK
5) Confidence 0.33 Published 2010 Journal CJEM Section Abstract Doc Link 20078923 Disease Relevance 0.36 Pain Relevance 0.17
Laboratory studies showed elevated creatine phosphokinase (CK), lactic dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels.
Positive_regulation (elevated) of Gene_expression (levels) of CK associated with disorders of creatine metabolism
6) Confidence 0.29 Published 2003 Journal Clin Neurol Neurosurg Section Abstract Doc Link 12954545 Disease Relevance 1.56 Pain Relevance 0.13
The authors stated that the serum CK level was statistically higher in EP patients than in controls, but the CK value distribution curve for EP was broad and overlapped with the control curve, indicating that the sensitivity and positive predictive value of this test were poor.44

CA 125

Positive_regulation (serum) of Gene_expression (level) of CK associated with ectopic pregnancy
7) Confidence 0.27 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.20 Pain Relevance 0.09
Total serum CK levels were found to be significantly higher in the EP group as compared to the controls (p < 0.001), suggesting that this test might be used as a indicator for EP.27
Positive_regulation (for) of Gene_expression (levels) of CK associated with ectopic pregnancy
8) Confidence 0.27 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.47 Pain Relevance 0.07
The authors stated that the serum CK level was statistically higher in EP patients than in controls, but the CK value distribution curve for EP was broad and overlapped with the control curve, indicating that the sensitivity and positive predictive value of this test were poor.44

CA 125

Positive_regulation (higher) of Gene_expression (level) of CK associated with ectopic pregnancy
9) Confidence 0.27 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.21 Pain Relevance 0.09
Total serum CK levels were found to be significantly higher in the EP group as compared to the controls (p < 0.001), suggesting that this test might be used as a indicator for EP.27
Positive_regulation (higher) of Gene_expression (levels) of CK associated with ectopic pregnancy
10) Confidence 0.27 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.38 Pain Relevance 0.07
Total serum CK levels were found to be significantly higher in the EP group as compared to the controls (p < 0.001), suggesting that this test might be used as a indicator for EP.27
Positive_regulation (serum) of Gene_expression (levels) of CK associated with ectopic pregnancy
11) Confidence 0.27 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.37 Pain Relevance 0.07
Total serum CK levels were found to be significantly higher in the EP group as compared to the controls (p < 0.001), suggesting that this test might be used as a indicator for EP.27
Positive_regulation (found) of Gene_expression (levels) of CK associated with ectopic pregnancy
12) Confidence 0.27 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.37 Pain Relevance 0.07
The trophoblast usually invades the muscle layer and maternal blood vessels are eroded, allowing muscle cell products such as CK to enter the circulation;26 therefore, increased serum CK levels are normal during EP.26,27 The pathology of arrested IUP and pelvic inflammatory disease are different, although both demonstrate no change in CK concentration.
Positive_regulation (increased) of Gene_expression (levels) of CK in muscle cell associated with inflammation, chlamydia infection and ectopic pregnancy
13) Confidence 0.25 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.10 Pain Relevance 0.05
Ovarian SE cells undergoing this epithelio-mesenchymal conversion are initially cytokeratin (CK) positive, but lose CK expression with time and passages in cultures [28].
Positive_regulation (lose) of Gene_expression (expression) of CK
14) Confidence 0.23 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC420494 Disease Relevance 0.06 Pain Relevance 0
Her serum CK level was elevated to 1,275 IU/L (normal; 5-275 IU/L), and other laboratory tests including ECG and chest radiography were unremarkable.
Positive_regulation (elevated) of Gene_expression (level) of CK in chest
15) Confidence 0.16 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693639 Disease Relevance 0.16 Pain Relevance 0.07
The one remaining AMI patient showed two subsequent peaks in serum CK-MB and myoglobin concentrations (thus suggesting an extension of myocardial necrosis), the myosin concentrations reaching their peak only after 9 days.
Positive_regulation (peaks) of Gene_expression (concentrations) of CK-MB associated with necrosis and myocardial infarction
16) Confidence 0.15 Published 1993 Journal J Nucl Biol Med Section Abstract Doc Link 8329475 Disease Relevance 0.72 Pain Relevance 0.14
The one remaining AMI patient showed two subsequent peaks in serum CK-MB and myoglobin concentrations (thus suggesting an extension of myocardial necrosis), the myosin concentrations reaching their peak only after 9 days.
Positive_regulation (serum) of Gene_expression (concentrations) of CK-MB associated with necrosis and myocardial infarction
17) Confidence 0.15 Published 1993 Journal J Nucl Biol Med Section Abstract Doc Link 8329475 Disease Relevance 0.72 Pain Relevance 0.14
The one remaining AMI patient showed two subsequent peaks in serum CK-MB and myoglobin concentrations (thus suggesting an extension of myocardial necrosis), the myosin concentrations reaching their peak only after 9 days.
Positive_regulation (after) of Gene_expression (concentrations) of CK-MB associated with necrosis and myocardial infarction
18) Confidence 0.15 Published 1993 Journal J Nucl Biol Med Section Abstract Doc Link 8329475 Disease Relevance 0.72 Pain Relevance 0.14
One subject in the placebo group but also one in the 400-mg group showed increased CK levels at one visit.
Positive_regulation (increased) of Gene_expression (levels) of CK
19) Confidence 0.08 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2426926 Disease Relevance 0.49 Pain Relevance 0.13

General Comments

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