INT20631

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Context Info
Confidence 0.69
First Reported 1984
Last Reported 2010
Negated 8
Speculated 1
Reported most in Abstract
Documents 166
Total Number 169
Disease Relevance 109.86
Pain Relevance 17.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CHKB)
Anatomy Link Frequency
muscle 22
upper 6
chest 5
plasma 4
joint 3
CHKB (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 1035 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Angina 439 99.92 Very High Very High Very High
Pain 193 99.92 Very High Very High Very High
cva 211 99.88 Very High Very High Very High
Inflammation 234 99.72 Very High Very High Very High
agonist 102 99.34 Very High Very High Very High
headache 25 99.16 Very High Very High Very High
anesthesia 44 98.80 Very High Very High Very High
ischemia 501 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myocardial Infarction 1150 100.00 Very High Very High Very High
Injury 496 100.00 Very High Very High Very High
Muscle Disease 362 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 176 100.00 Very High Very High Very High
Necrosis 466 99.96 Very High Very High Very High
Gastroenteritis 9 99.96 Very High Very High Very High
Rhabdomyolysis 930 99.92 Very High Very High Very High
Cv General 3 Under Development 222 99.92 Very High Very High Very High
Myalgia 170 99.92 Very High Very High Very High
Leukocytosis 1 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PURPOSE: Unaccustomed exercise is associated with an elevated plasma creatine kinase (CK), myofibrillar inflammation, and delayed onset muscle soreness (DOMS).
Positive_regulation (elevated) of CK in plasma associated with inflammation and myalgia
1) Confidence 0.69 Published 1999 Journal Med Sci Sports Exerc Section Abstract Doc Link 9927002 Disease Relevance 0.30 Pain Relevance 0.19
RESULTS: Exercise resulted in an increased CK activity at +24 and +48 h (vs preexercise: P < 0.01), with no treatment effect.
Positive_regulation (increased) of CK
2) Confidence 0.69 Published 1999 Journal Med Sci Sports Exerc Section Body Doc Link 9927002 Disease Relevance 0.21 Pain Relevance 0
In grade II lesions measurement of the serum markers showed an increase in CK activity, with the greatest increases being those of both types of myosin, reaching up to 10 times the normal value in some cases.
Positive_regulation (increase) of CK
3) Confidence 0.67 Published 2008 Journal British Journal of Sports Medicine Section Body Doc Link PMC2564766 Disease Relevance 0.07 Pain Relevance 0.07
After the embolization, the serum creatine kinase (CK) level increased transiently although there was no evidence of myocardial infarction.
Positive_regulation (increased) of CK associated with myocardial infarction
4) Confidence 0.67 Published 2000 Journal Intern. Med. Section Abstract Doc Link 10852167 Disease Relevance 0.70 Pain Relevance 0.07
The electromyography (EMG) was normal, the serum creatinine-kinase (CK) activity has not increased.
Neg (not) Positive_regulation (increased) of CK
5) Confidence 0.66 Published 1994 Journal Orv Hetil Section Abstract Doc Link 8015822 Disease Relevance 0.66 Pain Relevance 0.26
Laboratory studies showed elevated creatine kinase (CK) level (38,803 U/l; normal 62-287) and positive Jo-1 antibody, but no eosinophilia.
Positive_regulation (elevated) of CK associated with eosinophilia
6) Confidence 0.66 Published 2008 Journal Rinsho Shinkeigaku Section Abstract Doc Link 18386630 Disease Relevance 0.84 Pain Relevance 0.37
OBJECTIVE: To report a case of rosiglitazone-associated elevation in creatine kinase (CK) and coexisting myalgias and review other cases identified in the literature.
Positive_regulation (elevation) of CK
7) Confidence 0.65 Published 2007 Journal Ann Pharmacother Section Abstract Doc Link 17327290 Disease Relevance 0.07 Pain Relevance 0
On admission, CK-MB was elevated but troponin T was negative.
Positive_regulation (elevated) of CK
8) Confidence 0.64 Published 2006 Journal J Cardiol Section Abstract Doc Link 17136824 Disease Relevance 0.58 Pain Relevance 0.25
Elevated CK activity persisted but was not cardiogenic and instead due to the presence of elevated macro CK-1 associated with ulcerative colitis.
Positive_regulation (Elevated) of CK in cardiogenic associated with inflammatory bowel disease
9) Confidence 0.64 Published 2006 Journal J Cardiol Section Abstract Doc Link 17136824 Disease Relevance 0.66 Pain Relevance 0.25
Laboratory findings showed elevated serum creatine kinase (CK) at that time, so non-ST-elevated acute coronary syndrome was suspected and the patient was referred to our hospital.
Positive_regulation (elevated) of CK associated with acute coronary syndrome
10) Confidence 0.64 Published 2006 Journal J Cardiol Section Abstract Doc Link 17136824 Disease Relevance 0.58 Pain Relevance 0.24
His serum creatine kinase (CK) levels were found to be elevated.
Positive_regulation (elevated) of CK
11) Confidence 0.59 Published 2007 Journal Eur. J. Neurol. Section Abstract Doc Link 17437618 Disease Relevance 0.37 Pain Relevance 0.22
In subjects (n = 34) with skeletal muscle damage (total CK = 338 to 5384 IU/L), cardiac troponin-I levels were not elevated above normal, although CK-MB isoenzyme was elevated in some patients.
Positive_regulation (elevated) of CK-MB in skeletal muscle
12) Confidence 0.58 Published 1987 Journal Am. Heart J. Section Abstract Doc Link 3591601 Disease Relevance 0.43 Pain Relevance 0.09
The diagnostic criterion for MI related to CABG was an elevation of the CK-MB values to more than 100 units/l within the 24 h that followed surgery.
Positive_regulation (elevation) of CK-MB associated with myocardial infarction
13) Confidence 0.57 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.53 Pain Relevance 0.18
For those with elevated CK-MB, more than two times the upper limit of normal within 8 h after randomization, and with a decrease in CK-MB of more than 50% from the previous peak value, reinfarction was defined as an elevation of the value of CK-MB at or after 8 h to more than two times the upper limit of normal (three times in the case of PTCA) and 75% more than the preceding trough CK-MB values.
Positive_regulation (elevation) of CK-MB in upper
14) Confidence 0.57 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.42 Pain Relevance 0.13
CASE SUMMARY: A 42-year-old man originally from Sri Lanka developed an elevated CK, with peak concentrations of 1671 U/L (normal <160) and myalgias following 5 months of therapy with rosiglitazone.
Positive_regulation (elevated) of CK
15) Confidence 0.57 Published 2007 Journal Ann Pharmacother Section Body Doc Link 17327290 Disease Relevance 0 Pain Relevance 0
Previous studies have shown that levels of CK-MB are increased in the left ventricle of individuals with heart disease; however, it has not been established whether there are differences in the ventricular myocardium concentrations of cTnI in diseased compared to healthy hearts.
Positive_regulation (increased) of CK-MB in ventricle associated with heart disease
16) Confidence 0.57 Published 2002 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 11848617 Disease Relevance 0.39 Pain Relevance 0.09
METHODS: A 56-year-old man with a previous history of S1 root lesion presented with marked calf hypertrophy, muscle pain, cramps, fasciculations, and increased CK level.
Positive_regulation (increased) of CK in muscle
17) Confidence 0.55 Published 2005 Journal Clin Neurophysiol Section Body Doc Link 16256429 Disease Relevance 0.19 Pain Relevance 0
Laboratory data showed significant increase of serum CK, aldolase and myoglobin.
Positive_regulation (increase) of CK
18) Confidence 0.53 Published 1990 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2331815 Disease Relevance 0.54 Pain Relevance 0.03
Laboratory data showed a leukocytosis, an elevated serum creatinine kinase (CK) and marked eosionophilia.
Positive_regulation (elevated) of CK associated with leukocytosis
19) Confidence 0.52 Published 2002 Journal Neuropathology Section Abstract Doc Link 12564771 Disease Relevance 1.18 Pain Relevance 0.26
We observed only moderate increases in CK at 24 hours for the majority of subjects across both exposure groups.
Positive_regulation (increases) of CK
20) Confidence 0.51 Published 2010 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2850854 Disease Relevance 0.06 Pain Relevance 0

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