INT20632

Context Info Confidence 0.78 First Reported 1990 Last Reported 2010 Negated 4 Speculated 4 Reported most in Abstract Documents 72 Total Number 76 Disease Relevance 30.43 Pain Relevance 13.16

signal transduction (TNC) extracellular space (TNC) extracellular region (TNC) cell adhesion (TNC)

Anatomy Link Frequency TMJ 7 TMJ 3 connective tissue 3 stellate cells 2 fibroblasts 2 TNC (Homo sapiens)

Pain Link Frequency Relevance Heat Snapping jaw 75 100.00 Trigeminal neuralgia 66 100.00 headache 260 99.80 Inflammation 77 99.40 Chronic pancreatitis 8 98.84 fluoxetine 6 98.80 fibrosis 5 98.48 Pain 227 95.92 carbamazepine 213 95.40 palliative 92 95.08

Disease Link Frequency Relevance Heat Headache 290 100.00 Temporomandibular Joint Syndrome 74 100.00 Neuralgia 45 100.00 Disease 116 99.92 Pancreatic Cancer 23 99.84 Arthritis 6 99.64 Hypoxia 20 99.48 Adenocarcinoma 34 99.36 Fibrosis 12 99.08 Pancreatitis 13 98.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The specific expression of tenascin in the synovial membrane of the temporomandibular joint with internal derangement: an immunohistochemical study.

Gene_expression (expression) of tenascin in temporomandibular joint associated with snapping jaw

1) Confidence 0.78 Published 1997 Journal Histochem. Cell Biol. Section Title Doc Link 9243281 Disease Relevance 0.10 Pain Relevance 0.10

The present study demonstrates that tenascin is produced specifically in synovial cells, vascular endothelial cells and fibroblasts affected in the portion of TMJ with internal derangement.

Gene_expression (produced) of tenascin in internal associated with snapping jaw

2) Confidence 0.78 Published 2002 Journal J Oral Rehabil Section Abstract Doc Link 12220344 Disease Relevance 0.64 Pain Relevance 0.50

The expression of transforming growth factor beta (TGF-beta) in the synovial membrane of human temporomandibular joint with internal derangement: a comparison with tenascin expression.

Gene_expression (expression) of tenascin in internal associated with snapping jaw

3) Confidence 0.78 Published 1999 Journal J Oral Rehabil Section Title Doc Link 10564439 Disease Relevance 0.46 Pain Relevance 0.52

Tenascin C and annexin II expression in the process of pancreatic carcinogenesis.

Gene_expression (expression) of Tenascin C

4) Confidence 0.75 Published 2006 Journal J. Pathol. Section Title Doc Link 16450333 Disease Relevance 0.65 Pain Relevance 0.05

In this study, we clarify the contribution of hypoxia and interleukin-1beta in the expression of tenascin-C in ID of TMJ.

Gene_expression (expression) of tenascin-C in TMJ associated with snapping jaw and hypoxia

5) Confidence 0.75 Published 2008 Journal Oral Dis Section Abstract Doc Link 18173448 Disease Relevance 0.72 Pain Relevance 0.45

CONCLUSIONS: These results indicate that hypoxic conditions with inflammation modulate the tenascin-C expression in synovial fibroblasts, but not in disk cells.

Gene_expression (expression) of tenascin-C in fibroblasts

6) Confidence 0.75 Published 2008 Journal Oral Dis Section Body Doc Link 18173448 Disease Relevance 0.12 Pain Relevance 0

Morphometric analysis showed that tenascin-C expression by small arteries is correlated with PG-M/versican expression in surrounding connective tissue.

Gene_expression (expression) of tenascin-C in connective tissue

7) Confidence 0.75 Published 2006 Journal Histol. Histopathol. Section Abstract Doc Link 16493581 Disease Relevance 0.73 Pain Relevance 0.39

Although tenascin-C expression by synovial lining and connective tissue shows marked regional variation and seems inconsistent, in vitro examination suggested that tenascin-C production by these tissues is regulated in response to mechanical strain on the flexor tenosynovium.

Gene_expression (expression) of tenascin-C in connective tissue associated with sprains and strains

8) Confidence 0.75 Published 2006 Journal Histol. Histopathol. Section Abstract Doc Link 16493581 Disease Relevance 0.77 Pain Relevance 0.36

Although tenascin-C expression by synovial lining and connective tissue shows marked regional variation and seems inconsistent, in vitro examination suggested that tenascin-C production by these tissues is regulated in response to mechanical strain on the flexor tenosynovium.

Gene_expression (production) of tenascin-C in connective tissue associated with sprains and strains

9) Confidence 0.75 Published 2006 Journal Histol. Histopathol. Section Abstract Doc Link 16493581 Disease Relevance 0.73 Pain Relevance 0.34

OBJECTIVE: The expression of tenascin-C in the synovial membrane of the internal derangement (ID) of the temporomandibular joint (TMJ) has been reported.

Gene_expression (expression) of tenascin-C in TMJ associated with snapping jaw and hypoxia

10) Confidence 0.75 Published 2008 Journal Oral Dis Section Abstract Doc Link 18173448 Disease Relevance 0.53 Pain Relevance 0.43

Moreover, RNF13 staining was significantly correlated with Tenascin-C expression (P = 0.004) in PDAC samples, further supporting the role of RNF13 in cancer progression.

Gene_expression (expression) of Tenascin-C associated with adenocarcinoma and cancer

11) Confidence 0.75 Published 2009 Journal Cell Res. Section Abstract Doc Link 18794910 Disease Relevance 0.86 Pain Relevance 0.13

Effect of hypoxia and interleukin-1beta on expression of tenascin-C in temporomandibular joint.

Gene_expression (expression) of tenascin-C in temporomandibular joint associated with snapping jaw and hypoxia

12) Confidence 0.75 Published 2008 Journal Oral Dis Section Title Doc Link 18173448 Disease Relevance 0.57 Pain Relevance 0.47

An immunohistochemical and in situ hybridization study of the expression of tenascin in synovial membranes from human temporomandibular joints with internal derangement.

Gene_expression (expression) of tenascin in temporomandibular joints

13) Confidence 0.75 Published 1996 Journal Arch. Oral Biol. Section Title Doc Link 9068872 Disease Relevance 0.17 Pain Relevance 0.10

Major molecular changes include increased expression of type III collagen, fibronectin, tenascin C, aggrecan and biglycan.

Gene_expression (expression) of tenascin C

14) Confidence 0.75 Published 2008 Journal Nature clinical practice. Rheumatology Section Abstract Doc Link 18235537 Disease Relevance 0.48 Pain Relevance 0.06

Type I collagen, laminin, and tenascin were found in the framework of the sheath-like structure.

Gene_expression (found) of tenascin

15) Confidence 0.75 Published 1996 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 8665306 Disease Relevance 0.25 Pain Relevance 0.25

In 15 of 20 samples, ranging numbers of synovial cells expressed tenascin mRNA in the hypertrophic synovial membranes.

Gene_expression (expressed) of tenascin in synovial cells

16) Confidence 0.68 Published 2002 Journal J Oral Rehabil Section Abstract Doc Link 12220344 Disease Relevance 0.56 Pain Relevance 0.51

In control specimens, tenascin mRNA was not expressed.

Neg (not) Gene_expression (expressed) of tenascin

17) Confidence 0.68 Published 2002 Journal J Oral Rehabil Section Abstract Doc Link 12220344 Disease Relevance 0.57 Pain Relevance 0.47

However, we were able to find tenascin mRNA expression in the surgical specimens.

Gene_expression (expression) of tenascin

18) Confidence 0.68 Published 2002 Journal J Oral Rehabil Section Abstract Doc Link 12220344 Disease Relevance 0.57 Pain Relevance 0.52

The expression of tenascin mRNA in human temporomandibular joint specimens.

Gene_expression (expression) of tenascin in temporomandibular joint associated with snapping jaw

19) Confidence 0.68 Published 2002 Journal J Oral Rehabil Section Title Doc Link 12220344 Disease Relevance 0.61 Pain Relevance 0.56

The expression of tenascin mRNA was most evident in synovial cells.

Gene_expression (expression) of tenascin in synovial cells

20) Confidence 0.65 Published 1996 Journal Arch. Oral Biol. Section Abstract Doc Link 9068872 Disease Relevance 0.17 Pain Relevance 0.13

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