INT206426

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (SULT4A1, ASAP1) cytosol (SULT4A1) signal transduction (ASAP1)
small molecule metabolic process (SULT4A1) biological_process (SULT4A1)
SULT4A1 (Homo sapiens)
ASAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 24 42.44 Quite Low
Catecholamine 27 41.76 Quite Low
adenocard 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under the conditions of our screens, PAP bound to all hSULTs except for SULT4A1.
SULT4A1 Neg (except) Binding (bound) of PAP
1) Confidence 0.41 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0
In order to rule out the possibility that SULT4A1 simply has a much weaker affinity for PAP, we performed titration experiments for several of the proteins with increasing concentrations of PAP ranging from 90 ?
SULT4A1 Binding (affinity) of PAP
2) Confidence 0.30 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0
Although this is consistent with the inability of SULT4A1 to bind PAP and catalyze sulfonation, it is interesting to note that this is not due to a radical difference in local binding-site sequence or structure, because SULT4A1 clusters with SULT1C1 when considering these local factors (Figure 8B and 8C).
SULT4A1 Binding (bind) of PAP
3) Confidence 0.30 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0

General Comments

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