INT206433

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.25
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SULT1B1) small molecule metabolic process (SULT1B1) cytoplasm (SULT1B1)
SULT1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 4 86.08 High High
Paracetamol 3 74.56 Quite High
Bile 9 67.20 Quite High
Inflammation 3 61.84 Quite High
adenocard 2 36.08 Quite Low
agonist 13 21.48 Low Low
cINOD 2 21.48 Low Low
Catecholamine 9 14.92 Low Low
Dopamine 8 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 3 100.00 Very High Very High Very High
Colon Cancer 62 98.52 Very High Very High Very High
Cancer 45 74.48 Quite High
Breast Cancer 4 71.12 Quite High
Recurrence 10 65.76 Quite High
INFLAMMATION 4 61.84 Quite High
Lung Cancer 2 59.00 Quite High
Metastasis 8 58.64 Quite High
Hypoxia 1 58.08 Quite High
Apoptosis 4 23.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 5, PCP and DBHD were strong inhibitors of SULT1B1, whereas PLP and quercetin had intermediate effects.
Negative_regulation (inhibitors) of SULT1B1
1) Confidence 0.48 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0.12 Pain Relevance 0.03
High expression of SULT1B1 mRNA has been reported in normal colorectal samples, and it is thought to be related to carcinogenesis.30 Expression of SULT1B1 is a characteristic for normal colorectal tissue, so repression of SULT1B1 along with repression of UGT2B28 in CRC is thought to be related to tissue dedifferentiation.
Negative_regulation (repression) of SULT1B1 associated with colon cancer and repression
2) Confidence 0.18 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 1.12 Pain Relevance 0.04
The SULT1 family is divided into five subfamilies, designated SULT1A, SULT1B, SULT1C, SULT1D, and SULT1E.
Negative_regulation (designated) of SULT1B
3) Confidence 0.00 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.11

General Comments

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