INT206452

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.84
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HP)
HP (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 9 5.00 Very Low Very Low Very Low
Dopamine 8 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 68 100.00 Very High Very High Very High
Disease 2 100.00 Very High Very High Very High
Cancer 29 82.80 Quite High
Cardiovascular Disease 8 75.60 Quite High
Metastasis 1 66.12 Quite High
Death 2 21.60 Low Low
Renal Insufficiency 1 20.96 Low Low
Stroke 1 19.96 Low Low
Myocardial Infarction 3 19.64 Low Low
Heart Rate Under Development 2 18.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, control of BP is important for patients receiving VSP inhibitor therapy for the following five reasons:Serious adverse events have been associated with unmanaged hypertension (1–3,5,34), and these could be prevented with control of BP before and early in the course of VSP inhibitor therapy.These agents can cause dramatic increases in BP from pretreatment measurements (as high as 29 mmHg systolic and 27 mmHg diastolic in one prospective clinical investigation) (35) during the first week of treatment (35,36), and currently, it cannot be predicted which patients will have this magnitude of BP elevation.Although minimalist approaches to hypertension for patients with incurable disease might be favored in certain circumstances, management of comorbidities, including hypertension, could improve overall survival.
Negative_regulation (favored) of BP Binding (approaches) of associated with hypertension and disease
1) Confidence 0.04 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.84 Pain Relevance 0
Here we also reveal a previously unrecognized structural role for the cofactor PAP(S); namely priming of the often disordered substrate binding loops for interaction with substrates.
Negative_regulation (loops) of binding Binding (interaction) of
2) Confidence 0.03 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0

General Comments

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