INT206467

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 6.65
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IARS) nucleolus (IARS) nucleus (IARS)
ligase activity (IARS) cytoplasm (IARS)
Anatomy Link Frequency
IRS 4
cuticle 1
IARS (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 90 98.12 Very High Very High Very High
medulla 35 98.08 Very High Very High Very High
corticosteroid 37 92.40 High High
Infliximab 102 90.24 High High
Inflammation 40 65.96 Quite High
methotrexate 63 58.88 Quite High
headache 6 50.16 Quite High
Etanercept 3 40.56 Quite Low
Adalimumab 3 39.36 Quite Low
cva 6 32.28 Quite Low
Disease Link Frequency Relevance Heat
Infection 175 100.00 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 18 100.00 Very High Very High Very High
Metastasis 88 99.58 Very High Very High Very High
Prostate Cancer 86 99.36 Very High Very High Very High
Gastrointestinal Disease 6 98.60 Very High Very High Very High
Rheumatoid Arthritis 90 98.12 Very High Very High Very High
Disease 108 97.68 Very High Very High Very High
Mycobacterial Infection 72 94.84 High High
Viral Meningitis 3 89.16 High High
Skin Cancer 148 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Otherwise, we did not identify significant risk factors for AEs overall, SAEs, infections, or IRs in this study.
Gene_expression (overall) of IRs associated with infection
1) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911915 Disease Relevance 0.83 Pain Relevance 0.21
The most common SAE was infection (n = 47), followed by IRs (n = 15), cardiovascular events (n = 15), and RA-related disease manifestations (n = 11).
Gene_expression (infection) of IRs associated with rheumatoid arthritis, disease and infection
2) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911915 Disease Relevance 1.24 Pain Relevance 0.20
Fifteen of these IRs were recorded as SAEs, and 33 led to treatment discontinuation.
Gene_expression (recorded) of IRs
3) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911915 Disease Relevance 1.74 Pain Relevance 0.12
These IRS keratins are differentially and partially sequentially expressed in the various IRS compartments, the Henle layer, the Huxley layer, and the IRS cuticle.
Gene_expression (expressed) of IRS in IRS
4) Confidence 0.29 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0.07
These IRS keratins are differentially and partially sequentially expressed in the various IRS compartments, the Henle layer, the Huxley layer, and the IRS cuticle.
Gene_expression (expressed) of IRS in IRS
5) Confidence 0.25 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0.07
These IRS keratins are differentially and partially sequentially expressed in the various IRS compartments, the Henle layer, the Huxley layer, and the IRS cuticle.
Gene_expression (expressed) of IRS in IRS
6) Confidence 0.22 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0.07
K74 is restricted to the Huxley layer, whereas K73, K72 (Fig. 6c, h, i) and K28 are sequentially expressed in the IRS cuticle (Langbein et al. 2002, 2003, 2006; Langbein and Schweizer 2005; Fig. 6h, i).
Gene_expression (expressed) of IRS in IRS
7) Confidence 0.22 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0.07
To compare the IRs of two drugs, the IR ratio (IRR) was computed as IRR = IRA/IRC, where IRA is the point estimate of the IR with aceclofenac and IRC is the point estimate of the IR with the comparator drug (meloxicam or rofecoxib).
Gene_expression (compare) of IRs
8) Confidence 0.20 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936304 Disease Relevance 0.11 Pain Relevance 0
K71 (b) is expressed in all compartments and K72 (c) in the cuticle (icu) of the hair inner root sheath (IRS).
Gene_expression (expressed) of IRS in cuticle
9) Confidence 0.20 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.44 Pain Relevance 0.14
Therefore, in order to diagnose such conditions, the clinicians, histopathologists and microbiologists alike need to maintain a strong index of suspicion for making initial diagnosis as well as for suspecting IRS with rare fungal pathogens.


Gene_expression (suspecting) of IRS associated with immune reconstitution inflammatory syndrome
10) Confidence 0.10 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2089067 Disease Relevance 0.67 Pain Relevance 0
Both IRs then were scaled with the following scaling factors (Scf): 0.67, 0.8, 1.25, and 1.5.
Gene_expression (scaled) of IRs
11) Confidence 0.10 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847841 Disease Relevance 0.07 Pain Relevance 0
In the 20 samples from prostate cancer metastases the mean and median IRS of epithelial and stromal periostin expression did not differ from that in the primary prostate cancers.


Gene_expression (expression) of IRS associated with prostate cancer and metastasis
12) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2903527 Disease Relevance 0.75 Pain Relevance 0
Only 7.4% of cases exhibited an IRS for epithelial periostin expression above 6.
Gene_expression (expression) of IRS
13) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2903527 Disease Relevance 0.80 Pain Relevance 0

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