INT206471

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 36
Disease Relevance 25.75
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) plasma membrane (Ptk2)
cytoskeleton (Ptk2) nucleus (Ptk2) extracellular matrix organization (Ptk2)
Anatomy Link Frequency
brain 3
smooth muscle cell 3
myocardium 2
endothelial cell 2
4T1 1
Ptk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Mechanotransduction 22 99.64 Very High Very High Very High
Kinase C 1 98.82 Very High Very High Very High
chemokine 61 98.44 Very High Very High Very High
metalloproteinase 33 98.16 Very High Very High Very High
Inflammation 37 95.96 Very High Very High Very High
cytokine 62 90.36 High High
Central nervous system 103 82.32 Quite High
imagery 99 60.68 Quite High
alcohol 4 43.68 Quite Low
Morphine 2 31.20 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 470 100.00 Very High Very High Very High
Glioblastoma 46 99.96 Very High Very High Very High
Squamous Cell Carcinoma 72 99.84 Very High Very High Very High
Malignant Neoplastic Disease 51 99.70 Very High Very High Very High
Breast Cancer 62 99.46 Very High Very High Very High
Cancer 1796 99.40 Very High Very High Very High
Melanoma 189 99.02 Very High Very High Very High
Stress 53 99.02 Very High Very High Very High
Adenocarcinoma 11 98.52 Very High Very High Very High
Brain Tumor 16 98.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, TM also inhibited the activation of focal adhesion kinase (FAK), an important cell migration mediator (Fig. 4D).
Positive_regulation (activation) of FAK associated with adhesions
1) Confidence 0.51 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.86 Pain Relevance 0
Focal adhesion kinase (FAK) is the key member of the focal contact assembly and FAK activation is required for optimal cell motility [39].
Positive_regulation (activation) of FAK associated with adhesions
2) Confidence 0.51 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.23 Pain Relevance 0
Therefore, TM may be inhibiting tumor cell migration by inhibiting FAK activation via lysyl oxidase.
Positive_regulation (activation) of FAK associated with cancer
3) Confidence 0.51 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.02 Pain Relevance 0.04
TM treatment significantly inhibited FAK activation as well as the activation of LOX.
Positive_regulation (activation) of FAK
4) Confidence 0.51 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.19 Pain Relevance 0
Integrin clustering upon binding to extracellular matrix components, such as FN, or growth factor binding to their receptors results in activation of FAK [41].
Positive_regulation (activation) of FAK in extracellular matrix
5) Confidence 0.47 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.19 Pain Relevance 0.10
Firstly, shear stress and high intraluminal pressure were reported to activate integrins and FAK and up-regulate expression of FAK [34–36].
Positive_regulation (activate) of FAK associated with stress
6) Confidence 0.47 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.52 Pain Relevance 0.11
To gain insights into the genetic basis for skeletal mechanotransduction we conditionally inactivated focal adhesion kinase (FAK), an intracellular component of the integrin signaling pathway.
Positive_regulation (inactivated) of focal adhesion kinase associated with mechanotransduction and adhesions
7) Confidence 0.45 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1849965 Disease Relevance 0.19 Pain Relevance 0.17
To gain insights into the genetic basis for skeletal mechanotransduction we conditionally inactivated focal adhesion kinase (FAK), an intracellular component of the integrin signaling pathway.
Positive_regulation (inactivated) of FAK associated with mechanotransduction and adhesions
8) Confidence 0.45 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1849965 Disease Relevance 0.19 Pain Relevance 0.17
In addition, TM also inhibited the activation of focal adhesion kinase (FAK), an important cell migration mediator (Fig. 4D).
Positive_regulation (activation) of adhesion kinase associated with adhesions
9) Confidence 0.44 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.86 Pain Relevance 0
3 and in activation of FAK and smooth muscle cell proliferation.
Positive_regulation (activation) of FAK in smooth muscle cell
10) Confidence 0.44 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.13 Pain Relevance 0
FAK is activated by integrin clustering, also by various mechanical stimuli and soluble factors, and is considered as a key signal component at focal adhesions.
Positive_regulation (activated) of FAK associated with adhesions
11) Confidence 0.44 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.70 Pain Relevance 0
It has been suggested that FAK activation in an in vivo environment may synchronize MMP-mediated extracellular proteolysis and cell motility [23].
Positive_regulation (activation) of FAK
12) Confidence 0.44 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.43 Pain Relevance 0
In growing collateral vessels, upregulation of MMPs, fibronectin, and FAK have been observed, therefore we hypothesize that smooth muscle cell migration is partly regulated in arteriogenesis through a FAK inside-out signaling mechanism.
Positive_regulation (upregulation) of FAK in smooth muscle cell
13) Confidence 0.44 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.40 Pain Relevance 0
Because of the mechanism by which FAK is activated and the fact that FN and the integrin ?
Positive_regulation (activated) of FAK
14) Confidence 0.44 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.06 Pain Relevance 0.06
The ability of FAK to promote cell migration, proliferation, and invasion suggested that FAK could be necessary for endothelial cell sprouting and tube formation [6].
Positive_regulation (necessary) of FAK in endothelial cell
15) Confidence 0.44 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.82 Pain Relevance 0
Furthermore, when these studies were repeated on brain tumors from an intracerebral nude mouse xenograft model of malignant glioblastoma, FAK and pFAK were detected at increased levels in the tumors as compared to the hUCBSC-treated brain tumors.
Positive_regulation (increased) of pFAK in brain associated with malignant neoplastic disease, cancer, glioblastoma and brain tumor
16) Confidence 0.38 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 1.74 Pain Relevance 0
During catalytic deamination, LOX generates hydrogen peroxide, a species that can act as a chemoattractant for vascular smooth muscle cells [18] and breast cancer cells [20], and that also activates FAK and Src [20]; in this way, LOX may be able to indirectly modulate cell adhesion and motility [17], [48].
Positive_regulation (activates) of FAK in smooth muscle cells associated with breast cancer and adhesions
17) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.69 Pain Relevance 0
FAK activation in squamous cell carcinoma and lung adenocarcinoma has been shown to promote cell invasion [18,19].
Positive_regulation (activation) of FAK in lung associated with adenocarcinoma and squamous cell carcinoma
18) Confidence 0.34 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.70 Pain Relevance 0.04
TM treatment significantly decreased tumor cell motility and invasiveness by inhibiting lysyl oxidase (LOX) activity, FAK activation and MMP2 levels.
Positive_regulation (activation) of FAK associated with cancer
19) Confidence 0.34 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2922193 Disease Relevance 1.49 Pain Relevance 0.03
However, recent work has shown that LOX regulates a number of cellular functions including cell migration via the activation of FAK/Src pathway [41,24].
Positive_regulation (activation) of FAK
20) Confidence 0.34 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.07 Pain Relevance 0.04

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