INT206484

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.14
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Shh) Golgi apparatus (Shh) endoplasmic reticulum (Shh)
embryo development (Shh) cell-cell signaling (Shh) signal transducer activity (Shh)
Anatomy Link Frequency
tube 1
fibroblasts 1
interneurons 1
Shh (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 4 99.84 Very High Very High Very High
gABA 8 95.84 Very High Very High Very High
cytokine 24 95.48 Very High Very High Very High
Neurotransmitter 2 88.72 High High
bDMF 9 65.36 Quite High
Action potential 3 63.40 Quite High
Hippocampus 15 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
neurotrophin 3 4 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 12 96.20 Very High Very High Very High
Skin Cancer 4 95.52 Very High Very High Very High
Malignant Neoplastic Disease 8 94.36 High High
Injury 28 92.76 High High
Neurodegenerative Disease 12 91.12 High High
Necrosis 4 81.68 Quite High
Bacterial Infection 4 59.96 Quite High
Wound Healing 8 59.28 Quite High
Corneal Neovascularization 24 55.68 Quite High
Burns 24 17.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As described above in the in vitro experiment, the VEGF-promoted tube formation was not affected by further addition of cyclopamine, suggesting that Shh signaling is not not located downstream of VEGF signaling.
Neg (not) Localization (located) of Shh in tube
1) Confidence 0.75 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.09 Pain Relevance 0
In both cell types of Araki-Sasaki corneal epithelial cells and mouse fibroblasts, exogenous Shh did not affect the protein and mRNA expression level of TGF?
Localization (exogenous) of Shh in fibroblasts
2) Confidence 0.75 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.14 Pain Relevance 0.05
Upon Shh binding to the receptor composed of patched 1 (Ptc) and Smoothend (Smo), the Shh signal transmitter, Gli members, are activated and translocated to the cell nuclei for gene expression regulation.
Localization (translocated) of Shh
3) Confidence 0.71 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.63 Pain Relevance 0.04
1, VEGF, and MCP-1 until 24 h after Shh (2.5 ?
Localization (2.5) of Shh
4) Confidence 0.66 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.13 Pain Relevance 0.05
In addition, some of the factors with pro-neurogenic effects (such as NT-3 and Shh) can be secreted by GABAergic interneurons [62].
Localization (secreted) of Shh in interneurons associated with gabaergic
5) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.14 Pain Relevance 0.33

General Comments

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