INT206485

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.26
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nes) intracellular (Nes) cytoplasm (Nes)
Anatomy Link Frequency
precursor cell 2
NSCs 1
Nes (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 6 98.22 Very High Very High Very High
gABA 16 81.68 Quite High
Neurotransmitter 4 69.84 Quite High
hyperexcitability 2 66.56 Quite High
Hippocampus 65 61.16 Quite High
cytokine 4 39.00 Quite Low
Inflammation 2 38.60 Quite Low
chemokine 9 33.00 Quite Low
bDMF 18 30.64 Quite Low
GABAergic 9 25.44 Quite Low
Disease Link Frequency Relevance Heat
Viral Infection 13 99.42 Very High Very High Very High
Infection 48 98.24 Very High Very High Very High
Cytomegalovirus Infection 56 96.68 Very High Very High Very High
Neurodegenerative Disease 42 95.12 Very High Very High Very High
Injury 5 80.76 Quite High
Sensorineural Hearing Loss 1 65.28 Quite High
Convulsion 46 64.56 Quite High
Cerebral Palsy 1 64.00 Quite High
Intellectual Impairment 3 63.36 Quite High
INFLAMMATION 2 38.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the transplanted population, we observed rapid differentiation, with a decline in nestin-expressing ESNPs within 1 week following injection into the DG.
Negative_regulation (decline) of nestin
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.10 Pain Relevance 0.03
RT-PCR revealed that NeuroD1 and Vesicular Glutamate Transporter 1 (VGLUT1) [28] were up-regulated during differentiation (Fig. 3e), whereas nestin mRNA, indicative of the precursor cell stage, was down-regulated.
Negative_regulation (down) of nestin in precursor cell associated with glutamate
2) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.18 Pain Relevance 0.29
RT-PCR revealed that NeuroD1 and Vesicular Glutamate Transporter 1 (VGLUT1) [28] were up-regulated during differentiation (Fig. 3e), whereas nestin mRNA, indicative of the precursor cell stage, was down-regulated.
Negative_regulation (regulated) of nestin in precursor cell associated with glutamate
3) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.18 Pain Relevance 0.29
In addition, viral infection was demonstrated to cause a loss of NSCs expressing CD133 and nestin.
Negative_regulation (loss) of nestin in NSCs associated with viral infection
4) Confidence 0.21 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020957 Disease Relevance 1.80 Pain Relevance 0

General Comments

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