INT2065

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Context Info
Confidence 0.36
First Reported 1977
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 10.90
Pain Relevance 4.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (BTG3)
Anatomy Link Frequency
B-cell 1
lymphocytes 1
TMJ 1
BTG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 83 99.76 Very High Very High Very High
Snapping jaw 9 99.36 Very High Very High Very High
Infliximab 241 99.34 Very High Very High Very High
rheumatoid arthritis 371 97.72 Very High Very High Very High
Inflammatory marker 1 97.52 Very High Very High Very High
Inflammation 56 93.40 High High
withdrawal 8 93.08 High High
fibrosis 83 90.48 High High
agonist 2 89.20 High High
spinal inflammation 115 88.84 High High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 9 99.36 Very High Very High Very High
Congenital Anomalies 22 99.20 Very High Very High Very High
Trepenoma Infection 2 98.56 Very High Very High Very High
Immune System Diseases 4 98.20 Very High Very High Very High
Rheumatoid Arthritis 371 97.72 Very High Very High Very High
Arthritis 13 97.32 Very High Very High Very High
INFLAMMATION 61 97.20 Very High Very High Very High
Hypersensitivity 13 96.08 Very High Very High Very High
Anaemia 5 92.48 High High
Retroperitoneal Fibrosis 61 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional investigations, including ANA, ANCA, and serological testing for syphilis were negative.
ANA Binding (investigations) of associated with trepenoma infection
1) Confidence 0.36 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350140 Disease Relevance 0.95 Pain Relevance 0.29
These results indicate that the presence of serum ANAs does not coincide with aberrant B-cell-subset homeostasis.



ANA Binding (presence) of in B-cell
2) Confidence 0.35 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.35 Pain Relevance 0
The mechanism underlying the association between ANA positivity and infusion reactions remains unknown.
ANA Binding (association) of
3) Confidence 0.24 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779374 Disease Relevance 0.22 Pain Relevance 0.23
Tests for anti-dsDNA autoantibodies were performed at the start of infliximab treatment and, depending on the formation of ANA, at 6, 12, 18 and 24 months of treatment with the use of a radioimmunological test (Dade Behring, Paris, France) in accordance with the manufacturer's instructions.
ANA Binding (formation) of associated with infliximab
4) Confidence 0.21 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 0.06 Pain Relevance 0.16
RF, ANA, or HLA-B27 alone did not seem to be associated with a risk of TMJ abnormalities.
ANA Binding (associated) of in TMJ associated with snapping jaw and congenital anomalies
5) Confidence 0.21 Published 1993 Journal Scand J Dent Res Section Abstract Doc Link 8248736 Disease Relevance 1.44 Pain Relevance 0.97
blocking agents, both ANA and aPL were clearly associated with adalimumab treatment.
ANA Binding (associated) of associated with adalimumab
6) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.66 Pain Relevance 0.24
Immunoglobulin G anti-dsDNA autoantibodies were associated with positivity for ANA, and remained positive until the end of the study, including three of four positive patients who discontinued the treatment.
ANA Binding (positivity) of
7) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.25 Pain Relevance 0.43
The formation of ANA and anti-dsDNA autoantibodies was not linked to clinical events, namely infectious side effects, allergy or lack of efficacy.


ANA Binding (formation) of associated with hypersensitivity
8) Confidence 0.19 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 1.54 Pain Relevance 1.22
LR-ANA in AS sera invariably showed a homogeneous pattern of immunofluorescent staining with human granulocytes, occasionally reacted with human lymphocytes but did not react with other human and non-human substrates.
LR-ANA Neg (not) Binding (react) of in lymphocytes
9) Confidence 0.17 Published 1977 Journal J. Rheumatol. Section Abstract Doc Link 328881 Disease Relevance 0.82 Pain Relevance 0.35
The percentage of subjects having a positive ANA at a titer ?
ANA Binding (having) of
10) Confidence 0.12 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253705 Disease Relevance 0 Pain Relevance 0
The emergence of ANA or anti-DNA antibodies occasionally observed with TNF inhibitor was also not evident in either trial in treatment with tocilizumab.
ANA Binding (emergence) of
11) Confidence 0.07 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 1.26 Pain Relevance 0
One volunteer who also received 80 µg AMA1 without CPG had a normal ANA at baseline, with a mild elevation (1?
ANA Binding (baseline) of
12) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2491586 Disease Relevance 0.71 Pain Relevance 0.03
Less frequent monitoring using the more specific of these markers, i.e., monitoring anti-dsDNA alone, and checking ANA and RF if anti-dsDNA is positive or if clinical symptoms are present, is likely to be sufficient for future studies.
ANA Binding (checking) of
13) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2491586 Disease Relevance 0.24 Pain Relevance 0
One volunteer who also received 80 µg AMA1 without CPG had a normal ANA at baseline, with a mild elevation (1?
ANA Binding (had) of
14) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2491586 Disease Relevance 0.71 Pain Relevance 0.03
Drug-induced cases are not associated with ANA [16].


ANA Binding (associated) of
15) Confidence 0.02 Published 2006 Journal BMC Med Section Body Doc Link PMC1618394 Disease Relevance 1.70 Pain Relevance 0.69

General Comments

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