INT206514

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 3.25
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sciatic nerve 2
brain 2
dendritic arbors 1
Tg(CAG-EGFP)D4Nagy (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 520 99.96 Very High Very High Very High
imagery 91 98.92 Very High Very High Very High
Somatostatin 1 98.48 Very High Very High Very High
intrathecal 56 98.00 Very High Very High Very High
Sciatic nerve 65 97.32 Very High Very High Very High
Central nervous system 40 94.36 High High
gABA 19 84.16 Quite High
Inflammation 105 81.52 Quite High
chemokine 11 81.04 Quite High
Hippocampus 15 77.76 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 169 100.00 Very High Very High Very High
Aging 46 98.72 Very High Very High Very High
Multiple Sclerosis 88 98.24 Very High Very High Very High
Disease 112 93.88 High High
INFLAMMATION 114 81.52 Quite High
Skin Cancer 5 75.56 Quite High
Solid Tumor 5 73.04 Quite High
Apoptosis 59 67.12 Quite High
Overdose 4 67.08 Quite High
Cancer 196 59.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GAACUUCAGGGUCAGCUUG CCG) was directed against eGFP mRNA and was designed according to Caplen and coworkers (Caplen et al, 2001).
Transcription (directed) of eGFP
1) Confidence 0.59 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.26 Pain Relevance 0
Given that aging has been reported to lead to UPS impairment [13], we evaluated GFP protein (Figure 4; Figure S1) and mRNA expression (Figure 5) in aged cohorts of Degron mice to determine if aging alone would lead to an increase in GFP expression.
Transcription (expression) of GFP associated with aging
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.36 Pain Relevance 0.08
Although the mRNA levels of GFP are relatively high in the spinal cord, GFP protein expression in the spinal cord is very low in comparison to other regions of the brain.
Transcription (levels) of GFP in brain associated with spinal cord
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.30 Pain Relevance 0.10
Although the mRNA levels of GFP are relatively high in the spinal cord, GFP protein expression in the spinal cord is very low in comparison to other regions of the brain.
Transcription (expression) of GFP in brain associated with spinal cord
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.31 Pain Relevance 0.10
To verify the sensitivity of the GFP?
Transcription (sensitivity) of GFP
5) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.19 Pain Relevance 0.07
In the GIN transgenic line [35], GFP expression level is sufficient for in vivo imaging of somatostatin-positive interneurons, but the dense labeling of overlapping dendritic arbors prevented tracking of dendritic branches longer than ?
Transcription (level) of GFP in dendritic arbors associated with targeted disruption, somatostatin and imagery
6) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289876 Disease Relevance 0.10 Pain Relevance 0.17
Thin sections were incubated with a polyclonal rabbit anti-GFP antibody (MBL, 1?
Transcription (antibody) of anti-GFP
7) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.14 Pain Relevance 0
Reverse transcription quantitative PCR (qPCR) against eGFP mRNA transcripts recapitulated this transduction profile. mRNA transcripts for eGFP were approximately seven times more abundant for intrathecal than sciatic nerve delivery in lumbar DRG (Fig. 1E).
Transcription (transcripts) of eGFP in sciatic nerve associated with sciatic nerve and intrathecal
8) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2747840 Disease Relevance 0.06 Pain Relevance 0.42
Reverse transcription quantitative PCR (qPCR) against eGFP mRNA transcripts recapitulated this transduction profile. mRNA transcripts for eGFP were approximately seven times more abundant for intrathecal than sciatic nerve delivery in lumbar DRG (Fig. 1E).
Transcription (transcription) of eGFP mRNA in sciatic nerve associated with sciatic nerve and intrathecal
9) Confidence 0.14 Published 2009 Journal Mol Pain Section Body Doc Link PMC2747840 Disease Relevance 0.05 Pain Relevance 0.37
Mice homozygous for the FVB-TgN (GadGFP) 45704Swn transgene, on a FVB background (FVB-GFP; n?
Transcription (homozygous) of FVB-GFP
10) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.33 Pain Relevance 0.04
As suggested by the results presented in Figure 5B, while expression of EGFP mRNA by an hMSC-EGFP cell transplant decreased by 50% at day 1 post-transplantation as compared to cultured hMSC-EGFP cells, EGFP mRNA by an hMSC-NT3-EGFP cell transplant directly decreased by 80% at day 1 post-transplantation as compared to cultured hMSC-NT3-EGFP cells.
Transcription (expression) of EGFP
11) Confidence 0.06 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0 Pain Relevance 0.04
However, while EGFP mRNA expression then remained stable between day 1 and day 7 post-transplantation for an hMSC-EGFP cell transplant, EGFP mRNA expression further decreased between day 1 and day 7 post-transplantation for an hMSC-NT3-EGFP cell transplant.
Transcription (expression) of EGFP
12) Confidence 0.06 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0 Pain Relevance 0.06
However, while EGFP mRNA expression then remained stable between day 1 and day 7 post-transplantation for an hMSC-EGFP cell transplant, EGFP mRNA expression further decreased between day 1 and day 7 post-transplantation for an hMSC-NT3-EGFP cell transplant.
Transcription (expression) of EGFP
13) Confidence 0.06 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0 Pain Relevance 0.07
The GFP-MSCs were recruited to intact prostates at low levels (mean?
Transcription (The) of GFP
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944821 Disease Relevance 0.05 Pain Relevance 0.10
Then, we injected 5 × 106 TREM2 or control GFP vector–transduced BM-MC intravenously into EAE-diseased mice at 4 d after onset of first clinical symptoms, at a time period reflecting the peak of the disease.
Transcription (injected) of GFP associated with multiple sclerosis and disease
15) Confidence 0.06 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.81 Pain Relevance 0.32
While in vivo EGFP mRNA and protein expression by transplanted hMSC-EGFP cells was readily detectable at different time points post-transplantation, in vivo NT3 mRNA expression by hMSC-NT3 cells and in vivo EGFP protein expression by hMSC-NT3-EGFP cells was, respectively, undetectable or declined rapidly between day 1 and 7 post-transplantation.
Transcription (expression) of EGFP
16) Confidence 0.05 Published 2007 Journal BMC Biotechnol Section Abstract Doc Link PMC2225398 Disease Relevance 0.06 Pain Relevance 0.17
Next, at day 1 and day 7 post-transplantation, transplanted cell populations were isolated by LCM (Figure 5A) and the expression level of EGFP mRNA was analysed by real-time PCR.
Spec (analysed) Transcription (expression) of EGFP
17) Confidence 0.05 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0 Pain Relevance 0.05
Next, at day 1 and day 7 post-transplantation, transplanted cell populations were isolated by LCM (Figure 5A) and the expression level of EGFP mRNA was analysed by real-time PCR.
Spec (analysed) Transcription (level) of EGFP
18) Confidence 0.05 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0 Pain Relevance 0.05
To establish a standard RPC population curve, total RPC GFP+ signals were detected in populations from 1?
Transcription (detected) of GFP
19) Confidence 0.04 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0.08
Figure 1B shows a representative example for the detection of transgenic EGFP and NT3 DNA and mRNA by standard PCR and RT-PCR analysis on DNA and mRNA isolated from the different hMSC lines used in this study.
Transcription (detection) of EGFP associated with targeted disruption
20) Confidence 0.04 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.24 Pain Relevance 0.03

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