INT206528

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.91
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptprc) plasma membrane (Ptprc)
Anatomy Link Frequency
spinal cord 4
bone marrow 2
follicular B cells 2
Ptprc (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 139 99.08 Very High Very High Very High
Inflammation 234 88.32 High High
cytokine 88 87.28 High High
cINOD 13 78.52 Quite High
Hippocampus 7 76.56 Quite High
Central nervous system 113 62.60 Quite High
Nerve growth factor 8 46.64 Quite Low
agonist 14 34.96 Quite Low
Multiple sclerosis 85 33.88 Quite Low
Inflammatory response 4 25.88 Quite Low
Disease Link Frequency Relevance Heat
Infection 90 99.38 Very High Very High Very High
Multiple Sclerosis 302 98.94 Very High Very High Very High
Splenomegaly 2 97.44 Very High Very High Very High
Apoptosis 81 96.08 Very High Very High Very High
Disease 177 92.40 High High
Targeted Disruption 14 89.00 High High
INFLAMMATION 246 88.32 High High
Obesity 33 85.28 High High
Necrosis 7 82.04 Quite High
Cancer 17 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data collectively showed that cross-linking CD45RB boosts microglial phagocytosis of A?
Negative_regulation (linking) of Gene_expression (phagocytosis) of CD45RB
1) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.05 Pain Relevance 0
At day 4 after injection of BM-MC in EAE-diseased mice, 40.0% (SEM 7.2) of GFP+ cells showed reduced CD45 antigen expression compared to BM-MC before intravenous application (Figure 4E).
Negative_regulation (reduced) of Gene_expression (expression) of CD45 associated with multiple sclerosis
2) Confidence 0.25 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.50 Pain Relevance 0.46
Thus, BM-MC migrated into the spinal cord independently of TREM2 expression and showed down-regulated CD45 expression, but did not acquire a mature microglial phenotype and failed to show long-lasting engraftment.


Negative_regulation (regulated) of Gene_expression (expression) of CD45 in spinal cord associated with spinal cord
3) Confidence 0.18 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.64 Pain Relevance 0.43
Thus, BM-MC migrated into the spinal cord independently of TREM2 expression and showed down-regulated CD45 expression, but did not acquire a mature microglial phenotype and failed to show long-lasting engraftment.


Negative_regulation (down) of Gene_expression (expression) of CD45 in spinal cord associated with spinal cord
4) Confidence 0.18 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.64 Pain Relevance 0.43
and glial fibrillary acidic protein (GFAP) levels (Lim et al., 2000), and decreased expression of the microglial markers of activation CD45 and CD11b (Yan et al., 2003).
Negative_regulation (decreased) of Gene_expression (expression) of CD45
5) Confidence 0.14 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.73 Pain Relevance 0.21
Our studies provide further evidence that the mouse infection with T. vivax causes a marked reduction in the spleen of both B220+CD19+IgM+/hiIgDlo (MZB) and B220+CD19+IgMlo/hiIgDhi follicular B cells.
Negative_regulation (reduction) of Gene_expression (follicular B cells) of B220 in follicular B cells associated with infection
6) Confidence 0.14 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.68 Pain Relevance 0.05
The minimal requirement for a population of cells to qualify as MSCs, as suggested by the International Society for Cytotherapy, is threefold: (a) they must be plastic adherent under standard culture conditions, (b) they should express CD105, CD73, and CD90 and lack the expression of CD45, CD34, CD14 or CD11b, CD79?
Negative_regulation (lack) of Gene_expression (expression) of CD45
7) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.34 Pain Relevance 0
Subsequent to the initial description, the same group reported after in vitro expansion the SVF derived cells had surface marker expression similar to bone marrow derived MSC, comprising of positive for CD29, CD44, CD71, CD90, CD105/SH2, and SH3 and lacking CD31, CD34, and CD45 expression [24].
Negative_regulation (lacking) of Gene_expression (expression) of CD45 in bone marrow
8) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2679713 Disease Relevance 0.31 Pain Relevance 0.03

General Comments

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