INT206530

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.79
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.92
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp) nucleus (Mbp) cytoplasm (Mbp)
Anatomy Link Frequency
myeloid cells 1
T cells 1
Mbp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 104 98.64 Very High Very High Very High
Spinal cord 92 87.10 High High
metalloproteinase 80 60.04 Quite High
Demyelination 22 58.52 Quite High
cytokine 42 46.24 Quite Low
imagery 4 22.40 Low Low
Central nervous system 72 5.00 Very Low Very Low Very Low
Multiple sclerosis 34 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 108 98.64 Very High Very High Very High
Alzheimer's Dementia 24 92.20 High High
Multiple Sclerosis 176 81.12 Quite High
Adhesions 4 69.76 Quite High
Disease 126 59.88 Quite High
Demyelinating Disease 22 58.52 Quite High
Injury 10 57.76 Quite High
Apoptosis 50 46.96 Quite Low
Cancer 6 33.12 Quite Low
Necrosis 6 32.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, we investigated in vivo the distribution of degenerated myelin basic protein (MBP) immunoreactivity, which has been phagocytosed and degraded in lysosomes by myeloid cells in inflammatory lesions.
Protein_catabolism (degraded) of MBP in myeloid cells associated with inflammation
1) Confidence 0.79 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.50 Pain Relevance 0.20
After microwave pretreatment in 10 mM citric acid, the following antibodies were used for immunohistochemical analysis of the spinal cord tissue: monoclonal rat anti-mouse MAC3 (clone M3/84, dilution: 1:200, BD Biosciences Pharmingen) for macrophage staining, monoclonal rat anti-human/mouse CD3 (clone CD3–12, dilution: 1:200, Serotec Laboratories) for T cells, monoclonal mouse anti-amyloid precursor protein (APP) (clone 22C11, dilution: 1:100, Chemicon, Temecula, California, United States) for axonal degeneration, monoclonal mouse anti-SMI 32 (dilution: 1:200, Sternberger Monoclonals, Lutherville, Massachusetts, United States) for the detection of dephosphorylated neurofilament, and polyclonal rabbit anti-myelin basic protein (dMBP, AB5864, dilution 1:2000, Chemicon) for degraded MBP.
Protein_catabolism (degraded) of MBP in T cells associated with alzheimer's dementia and spinal cord
2) Confidence 0.46 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.28 Pain Relevance 0.24
Following cloning, the first catalytic activity assigned to the enzyme was its ability to degrade myelin basic protein (MBP) [48].
Protein_catabolism (degrade) of MBP
3) Confidence 0.25 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.07 Pain Relevance 0.03
Following cloning, the first catalytic activity assigned to the enzyme was its ability to degrade myelin basic protein (MBP) [48].
Protein_catabolism (degrade) of myelin basic protein
4) Confidence 0.25 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox