INT206532

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.93
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mc (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 7 97.28 Very High Very High Very High
antagonist 6 95.52 Very High Very High Very High
cytokine 40 89.64 High High
Inflammation 102 87.60 High High
Central nervous system 72 79.20 Quite High
Inflammatory mediators 2 64.12 Quite High
colic 3 43.76 Quite Low
Spinal cord 92 30.88 Quite Low
Multiple sclerosis 34 5.00 Very Low Very Low Very Low
Demyelination 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 50 98.00 Very High Very High Very High
INFLAMMATION 107 87.60 High High
Multiple Sclerosis 176 59.20 Quite High
Hypertension 5 54.76 Quite High
Diarrhoea 4 44.32 Quite Low
Abdominal Cramps 3 43.76 Quite Low
Disease 46 34.48 Quite Low
Toxicity 4 33.52 Quite Low
Demyelinating Disease 22 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These finding suggest that the vasodilatory response of Mc.Cr is mediated through inhibition of receptor and voltage operated calcium channels and inhibition of release of calcium from intracellular stores.
Localization (response) of Mc associated with calcium channel
1) Confidence 0.20 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2829485 Disease Relevance 0.11 Pain Relevance 0.12
Transduction by TREM2 enabled BM-MC to release a substantial amount of IL-10 after stimulation as determined by ELISA (Figure 3D).
Localization (release) of BM-MC
2) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.39 Pain Relevance 0.30
In detail, TREM2-transduced BM-MC released 130 pg/ml IL-10 (SEM 52) after stimulation with LPS- and TREM2-specific antibodies (Figure 3D).


Localization (released) of BM-MC
3) Confidence 0.01 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.44 Pain Relevance 0.31

General Comments

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