INT206539

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Trem2, Mapk1) nucleoplasm (Mapk1) mitochondrion (Mapk1)
protein complex (Mapk1) cytoplasm (Mapk1) cytosol (Mapk1)
Anatomy Link Frequency
CD86 2
Trem2 (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 51 82.40 Quite High
cytokine 20 81.36 Quite High
Inflammatory mediators 1 70.16 Quite High
Spinal cord 46 5.00 Very Low Very Low Very Low
Central nervous system 36 5.00 Very Low Very Low Very Low
Multiple sclerosis 17 5.00 Very Low Very Low Very Low
Demyelination 11 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 25 92.64 High High
INFLAMMATION 53 82.40 Quite High
Vesicular Stomatitis 1 43.76 Quite Low
Cytomegalovirus Infection 4 39.04 Quite Low
Multiple Sclerosis 88 34.64 Quite Low
Disease 22 5.00 Very Low Very Low Very Low
Demyelinating Disease 11 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Immunization 3 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TREM2 cross-linking antibodies stimulated phosphorylation of ERK in TREM2-transduced BM-MC (Figure 3), but did not modify cell surface expression of MHC class II, CD80, CD86, CD36, CCR7, and CD11c (Figure S1).
TREM2 Neg (not) Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of ERK in CD86
1) Confidence 0.22 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.62 Pain Relevance 0.20

General Comments

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