INT206586

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 6.64
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Artmd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 138 99.14 Very High Very High Very High
cocaine 423 93.68 High High
Hippocampus 3 87.96 High High
Inflammation 12 84.40 Quite High
depression 215 66.80 Quite High
tolerance 2 66.80 Quite High
long-term potentiation 18 64.40 Quite High
Nucleus accumbens 72 46.80 Quite Low
Morphine 156 46.56 Quite Low
Eae 180 42.88 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 1028 99.96 Very High Very High Very High
Reprotox - General 1 94 98.48 Very High Very High Very High
Renal Disease 18 98.32 Very High Very High Very High
Targeted Disruption 20 96.56 Very High Very High Very High
Death 7 95.08 Very High Very High Very High
Cancer 14 89.24 High High
Systemic Lupus Erythematosus 32 89.04 High High
Proteinuria 8 86.08 High High
INFLAMMATION 12 84.40 Quite High
Autoimmune Disease 8 77.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The significance of the gene expression trends of AMD1, BNIP3, GRB10, MARCKSL1, NGRAP1, ODC1, PPP2CB, PPP2R1A, SLC25A4, SLC25A6, and WDR45L that function in cell growth or cell death/survival were not straightforward.
Gene_expression (expression) of AMD1 associated with death
1) Confidence 0.30 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 0.84 Pain Relevance 0
In order to study the role of C4bp deficiency in an established murine model of lupus nephritis, mice with a targeted deletion in the gene encoding C4bp were backcrossed into the MRL/lpr genetic background.
Gene_expression (background) of MRL associated with renal disease
2) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212569 Disease Relevance 0.76 Pain Relevance 0.04
The KO MRL mice kidneys and the CTRL MRL mice kidneys had similar degrees of C1q and C4 (P = 0.55 and P = 1.0, respectively; Table 2).
Gene_expression (kidneys) of KO MRL
3) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.27 Pain Relevance 0.03
DBA pup raised by a DBA mother), the experimental group is raised by a non-isogenic mother (e.g.
Gene_expression (mother) of DBA
4) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373927 Disease Relevance 0.30 Pain Relevance 0.07
16.07; DBA-AKR F(6,42)?
Gene_expression (16.07) of DBA
5) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373927 Disease Relevance 0.16 Pain Relevance 0.16
8 for DBA dams).
Gene_expression (dams) of DBA
6) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373927 Disease Relevance 0.19 Pain Relevance 0
Considering nursing posture, biological DBA mothers showed higher levels compared to both foster mothers (mother strain effect F(2,21)?
Gene_expression (mothers) of DBA associated with sprains and strains
7) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373927 Disease Relevance 0.75 Pain Relevance 0
63.16 p<0.001, DBA-bio: F(1,9)?
Gene_expression (bio) of DBA
8) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373927 Disease Relevance 0.26 Pain Relevance 0.12
14.79; DBA-bio F(6,54)?
Gene_expression (14.79) of DBA
9) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373927 Disease Relevance 0.16 Pain Relevance 0.19
Both mother strains showed less nursing with DBA pups than with C57 pups (pup strain effect F(1,28)?
Gene_expression (pups) of DBA associated with sprains and strains
10) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373927 Disease Relevance 1.50 Pain Relevance 0
22.4 p<0.01, DBA-AKR: F(1,7)?
Gene_expression (p<0.01) of DBA
11) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373927 Disease Relevance 0.26 Pain Relevance 0.12
63.16 p<0.001, DBA-bio: F(1,9)?
Gene_expression (p<0.001) of DBA
12) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373927 Disease Relevance 0.26 Pain Relevance 0.12
In summary, there are multiple mRNAs that show differential expression between the C57 and DBA strains.
Gene_expression (expression) of DBA associated with sprains and strains
13) Confidence 0.02 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.40 Pain Relevance 0.29
In the current study we observed increased expression of Comt in C57, as compared to DBA, and increased expression of 1810037I17Rik in DBA, with a very significant main effect of strain (P = 7.83 × 10-7).
Gene_expression (expression) of DBA associated with catechol-o-methyltransferase and sprains and strains
14) Confidence 0.02 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.26 Pain Relevance 0.26
This same study identified a decrease in expression of Riken cDNA 1810037i17 in C57, compared with DBA, and a positive correlation of expression of this gene with aggressive behaviors.
Gene_expression (expression) of DBA
15) Confidence 0.02 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.26 Pain Relevance 0.26

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