INT206590

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.34
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
Artmd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 92 99.66 Very High Very High Very High
Nucleus accumbens 48 97.72 Very High Very High Very High
fibrosis 5 92.60 High High
Morphine 98 92.48 High High
Inflammation 6 92.04 High High
tail-flick 2 86.48 High High
Opioid 2 81.52 Quite High
Dopamine 22 78.40 Quite High
Ventral tegmentum 10 75.76 Quite High
Pain 4 75.20 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 173 99.38 Very High Very High Very High
Hyperplasia 2 96.96 Very High Very High Very High
Fibrosis 5 92.60 High High
INFLAMMATION 6 92.04 High High
Renal Disease 9 90.72 High High
Disease 14 87.28 High High
Pain 4 75.20 Quite High
Urological Neuroanatomy 20 73.28 Quite High
Proteinuria 4 71.32 Quite High
Renal Insufficiency 1 61.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Scoring revealed a modest decrease in glomerulosclerosis in KO MRL mice (Table 2) but there was large variability between mice, which impacted the statistical significance (P = 0.09).
Negative_regulation (decrease) of KO MRL
1) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.88 Pain Relevance 0.09
We first noted that in those studies of whole brain homogenates, Comt expression was significantly decreased in DBA, as compared to C57, consistent with our studies in the NAC.
Negative_regulation (decreased) of DBA in brain associated with nucleus accumbens and catechol-o-methyltransferase
2) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.23 Pain Relevance 1.14
In recent QPCR analyses of striata from four strains of mice, Comt was found to be downregulated in DBA, as compared to C57 [24], consistent with the microarray, QPCR and enzyme activity results presented here.
Negative_regulation (downregulated) of DBA associated with catechol-o-methyltransferase and sprains and strains
3) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.23 Pain Relevance 0.61

General Comments

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