INT206592

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.47
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (Nlrp1a) nucleus (Nlrp1a) enzyme binding (Nlrp1a)
Anatomy Link Frequency
interneurons 2
Nlrp1a (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 29 100.00 Very High Very High Very High
Nucleus accumbens 25 100.00 Very High Very High Very High
Dopamine 25 100.00 Very High Very High Very High
Glutamate 3 100.00 Very High Very High Very High
gABA 7 99.80 Very High Very High Very High
Morphine 64 98.42 Very High Very High Very High
Ventral tegmentum 6 93.60 High High
antagonist 17 89.24 High High
withdrawal 20 79.96 Quite High
Catechol-O-methyltransferase 46 79.88 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 10 94.80 High High
Recurrence 19 84.24 Quite High
Sprains And Strains 84 79.32 Quite High
Drug Dependence 20 49.12 Quite Low
Nicotine Addiction 8 5.00 Very Low Very Low Very Low
Opiate Addiction 7 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Alcohol Addiction 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the case of morphine, binding of morphine to GABA interneurons reduces GABA release, thereby reducing the GABA-mediated inhibition of dopamine release in the NAC, with a net result of increasing dopamine levels.
Negative_regulation (inhibition) of Localization (release) of NAC in interneurons associated with nucleus accumbens, dopamine, gaba and morphine
1) Confidence 0.06 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.17 Pain Relevance 0.98
CB1 receptor-mediated disinhibition of NAc glutamate release could activate presynaptic mGluR2/3 receptors, which then inhibited cocaine-enhanced NAc glutamate release and cocaine-triggered reinstatement of drug-seeking behavior (Xi et al 2006).
Negative_regulation (inhibited) of Localization (release) of NAc associated with glutamate and cocaine
2) Confidence 0.03 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656312 Disease Relevance 0.29 Pain Relevance 0.77

General Comments

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