INT206593

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.68
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) methyltransferase activity (Comt) plasma membrane (Comt)
Anatomy Link Frequency
tail 2
brain 2
Comt (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 173 100.00 Very High Very High Very High
tail-flick 2 99.76 Very High Very High Very High
Morphine 101 98.84 Very High Very High Very High
Nucleus accumbens 63 97.44 Very High Very High Very High
Opioid 2 94.56 High High
Dopamine 67 92.36 High High
Pain 10 88.24 High High
Hippocampus 29 86.24 High High
dopamine receptor 9 53.76 Quite High
Ventral tegmentum 16 48.48 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 337 99.88 Very High Very High Very High
Aggression 6 96.40 Very High Very High Very High
Cognitive Disorder 18 94.56 High High
Pain 10 88.24 High High
Urological Neuroanatomy 20 31.52 Quite Low
Disease 12 5.00 Very Low Very Low Very Low
Depression 10 5.00 Very Low Very Low Very Low
Drug Dependence 9 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Dislocations 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We first noted that in those studies of whole brain homogenates, Comt expression was significantly decreased in DBA, as compared to C57, consistent with our studies in the NAC.
Negative_regulation (decreased) of Gene_expression (expression) of Comt in brain associated with nucleus accumbens and catechol-o-methyltransferase
1) Confidence 0.56 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.23 Pain Relevance 1.15
Since the DBA mice showed increased sensitivity to morphine compared to C57, as defined by the tail flick assay, and reduction in Comt expression and activity, we sought to determine the degree to which morphine sensitivity varied in C57/DBA recombinant inbred strains, as a function of Comt expression, making use of the WebQTL database [13].
Negative_regulation (reduction) of Gene_expression (expression) of Comt in tail associated with catechol-o-methyltransferase, tail-flick, sprains and strains and morphine
2) Confidence 0.49 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.32 Pain Relevance 0.96
What sets of higher order phenotypes are downstream of the Comt polymorphism?
Negative_regulation (downstream) of Gene_expression (polymorphism) of Comt
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.32 Pain Relevance 0.19
All crosses derived from strains that differed in Comt expression show strong cis-modulation.
Negative_regulation (differed) of Gene_expression (expression) of Comt associated with sprains and strains
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.49 Pain Relevance 0.04
This study identifies the key sequence variant that leads to differences in Comt mRNA and protein levels among mice, and that modulates synaptic function and pharmacological and behavioral traits.


Negative_regulation (differences) of Gene_expression (levels) of Comt
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2923157 Disease Relevance 0.33 Pain Relevance 0.18

General Comments

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