INT206596

Context Info Confidence 0.41 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.93 Pain Relevance 1.20

cell proliferation (Gnb1) signal transduction (Gnb1) GTPase activity (Gnb1) signal transducer activity (Gnb1)

Gnb1 (Mus musculus)

Pain Link Frequency Relevance Heat cocaine 18 99.68 Nucleus accumbens 48 97.80 Morphine 98 90.44 withdrawal 4 83.52 Locus ceruleus 6 80.16 Dopamine 22 67.36 Ventral tegmentum 10 64.24 Physical dependence 2 61.52 Catechol-O-methyltransferase 92 60.24 opiate 4 59.68

Disease Link Frequency Relevance Heat Urological Neuroanatomy 20 99.68 Sprains And Strains 166 99.12 Drug Dependence 6 61.52 Pain 4 38.40 Depression 10 5.00 Adhesions 4 5.00 Dislocations 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Antisense disruption of Gnb1 expression blocks cocaine-induced sensitization, but without affecting the acute responses to cocaine [31].

Negative_regulation (disruption) of Gene_expression (expression) of Gnb1 associated with cocaine

1) Confidence 0.41 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.49 Pain Relevance 0.80

Moreover, in that study Gnb1 also showed decreased expression in the FC in the DBA strain.

Negative_regulation (decreased) of Gene_expression (expression) of Gnb1 associated with urological neuroanatomy and sprains and strains

2) Confidence 0.35 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.44 Pain Relevance 0.40

General Comments

This test has worked.