INT206598

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.00
Pain Relevance 3.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) methyltransferase activity (Comt) plasma membrane (Comt)
Anatomy Link Frequency
hippocampus 4
hypothalamus 2
frontal cortex 2
Comt (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 194 100.00 Very High Very High Very High
Pain 104 100.00 Very High Very High Very High
Hippocampus 31 99.52 Very High Very High Very High
Lasting pain 23 99.20 Very High Very High Very High
Dopamine 78 97.60 Very High Very High Very High
Morphine 102 78.96 Quite High
sSRI 68 73.96 Quite High
adenocard 3 67.16 Quite High
depression 16 62.28 Quite High
cocaine 20 59.52 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 345 100.00 Very High Very High Very High
Pain 132 100.00 Very High Very High Very High
Urological Neuroanatomy 22 99.68 Very High Very High Very High
Anxiety Disorder 426 98.72 Very High Very High Very High
Targeted Disruption 13 86.52 High High
Disease 16 81.56 Quite High
Cognitive Disorder 38 81.20 Quite High
Nociception 8 78.48 Quite High
Aggression 10 78.20 Quite High
Congenital Anomalies 14 68.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, changes in Comt1 expression altered many different behaviors in mice but the directionality of these differences was only somewhat similar to what has been observed in humans.
Regulation (changes) of Gene_expression (expression) of Comt1
1) Confidence 0.60 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2958038 Disease Relevance 0.73 Pain Relevance 0.07
UTR length that segregates among BXD strains and is the sole cause of cis-regulation of Comt expression.
Regulation (regulation) of Gene_expression (expression) of Comt associated with sprains and strains
2) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.41 Pain Relevance 0.06
There was, however, an interaction between pain status and the Met allele (N2-component of C4), indicating that the effect of the COMT Met allele on the pain ERP was moderated by the presence of chronic pain complaints.
Regulation (moderated) of Gene_expression (effect) of COMT Met associated with pain and lasting pain
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 1.87 Pain Relevance 1.76
We mapped this variation in Comt expression in several crosses, including the large BXD family.
Regulation (variation) of Gene_expression (expression) of Comt
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.59 Pain Relevance 0.07
In addition, microarray studies in the hippocampus of eight mouse strains demonstrated highest expression of Comt in C57, amongst all the strains (including DBA), and a significant inverse correlation of Comt expression with aggressive behaviors [17].
Regulation (demonstrated) of Gene_expression (expression) of Comt in hippocampus associated with catechol-o-methyltransferase, hippocampus and sprains and strains
5) Confidence 0.38 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.31 Pain Relevance 0.26
In addition, microarray studies in the hippocampus of eight mouse strains demonstrated highest expression of Comt in C57, amongst all the strains (including DBA), and a significant inverse correlation of Comt expression with aggressive behaviors [17].
Regulation (correlation) of Gene_expression (expression) of Comt in hippocampus associated with catechol-o-methyltransferase, hippocampus and sprains and strains
6) Confidence 0.38 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.27 Pain Relevance 0.29
In contrast, estrogen deficiency had no impact on COMT expression in the frontal cortex of male ArKO mice.
Neg (no) Regulation (impact) of Gene_expression (expression) of COMT in frontal cortex associated with catechol-o-methyltransferase and urological neuroanatomy
7) Confidence 0.33 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.67 Pain Relevance 0.42
The expression of Comt in this family of strains varies over 2-fold in several CNS regions and is strongly modulated by a polymorphism located within Comt itself [13].
Regulation (modulated) of Gene_expression (expression) of Comt associated with sprains and strains
8) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.58 Pain Relevance 0.20
The OCD-like behaviors of male ArKO mice are suggested to be caused by dysregulation of estrogen-induced catechol-O-methyltransferase (COMT) expression in the hypothalamus.
Regulation (dysregulation) of Gene_expression (expression) of COMT in hypothalamus associated with catechol-o-methyltransferase and anxiety disorder
9) Confidence 0.20 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.57 Pain Relevance 0.42

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox