INT2066

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Context Info
Confidence 0.80
First Reported 1977
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 56
Total Number 59
Disease Relevance 9.95
Pain Relevance 16.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
brain 6
lung 3
spinal cord 2
kidney 2
plasma 1
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 58 100.00 Very High Very High Very High
substance P 27 100.00 Very High Very High Very High
Catecholamine 27 100.00 Very High Very High Very High
Enkephalin 23 100.00 Very High Very High Very High
Dopamine 20 100.00 Very High Very High Very High
gABA 18 100.00 Very High Very High Very High
Calcitonin gene-related peptide 18 100.00 Very High Very High Very High
Neuropeptide 17 100.00 Very High Very High Very High
analgesia 10 100.00 Very High Very High Very High
Somatostatin 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 98 100.00 Very High Very High Very High
Hypertension 216 99.96 Very High Very High Very High
Injury 28 99.86 Very High Very High Very High
Targeted Disruption 28 99.78 Very High Very High Very High
Hypoxia 274 99.16 Very High Very High Very High
Cough 9 98.92 Very High Very High Very High
Natriuresis 13 98.44 Very High Very High Very High
Diuresis 6 97.80 Very High Very High Very High
Ureteral Obstruction 3 96.40 Very High Very High Very High
Prolactinoma 20 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Possible indirect mediation of the antinatriuresis by other humoral agents known to be released from the kidney on renal nerve stimulation (angiotensin II, prostaglandin) was excluded by experiments with appropriate blocking agents.
Localization (released) of angiotensin II in kidney
1) Confidence 0.80 Published 1977 Journal Am. J. Physiol. Section Abstract Doc Link 329687 Disease Relevance 0.07 Pain Relevance 0.14
The purpose of the present study was to determine whether Ang II releases adenosine from the perfused rat lung.
Localization (releases) of Ang II in lung associated with adenocard
2) Confidence 0.78 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1696651 Disease Relevance 0 Pain Relevance 0.13
Infusion of the Ang II selective antagonist, (1-Sar-8-Ile)-Ang II, blocked Ang II-induced [3H]adenosine release.
Localization (release) of Ang II associated with adenocard and antagonist
3) Confidence 0.78 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1696651 Disease Relevance 0 Pain Relevance 0.50
In this context, Lochard et al. [17] reported that Ang IV can mobilize [Ca2+]i via AT1 receptors mediated by an allosteric mechanism and that AT1 receptor antagonist can block the hypertension in transgenic mice with Ang IV release in the brain.
Localization (release) of Ang IV in brain associated with targeted disruption, antagonist and hypertension
4) Confidence 0.78 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.73 Pain Relevance 0.05
Experiments were performed three or more times and the enzyme activity values were reported as fmoles of Ang product formation from 125I-Ang-(1–12) substrate per min per mg protein (fmol·mg protein?
Localization (fmoles) of Ang
5) Confidence 0.75 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.08 Pain Relevance 0
Brain renin angiotensin system (RAS) in stress-induced analgesia and impaired retention.
Localization (retention) of angiotensin system in Brain associated with stress and analgesia
6) Confidence 0.74 Published 1999 Journal Peptides Section Title Doc Link 10447091 Disease Relevance 0.65 Pain Relevance 0.48
[Angiotensin II release and anti-electroacupuncture analgesia in spinal cord].
Localization (release) of Angiotensin in spinal cord associated with electroacupuncture, spinal cord and analgesia
7) Confidence 0.74 Published 1996 Journal Sheng Li Xue Bao Section Title Doc Link 9389152 Disease Relevance 0 Pain Relevance 0.97
Since Ang II also plays a role in controlling reproductive functions, such as luteinizing hormone and prolactin secretion, the objective of the present study was to evaluate the regulation of Ang II receptors by estradiol (E(2)) and progesterone (P) in areas of the brain involved in homeostatic and reproductive functions, such as the locus coeruleus (LC), median preoptic nucleus (MnPO) and subfornical organ (SFO).
Localization (secretion) of Ang II in subfornical organ associated with locus ceruleus
8) Confidence 0.74 Published 2005 Journal Brain Res. Section Abstract Doc Link 16297888 Disease Relevance 0.05 Pain Relevance 0.20
To investigate whether Ang IV stimulates intracellular Ca2+ response in the carotid body, the [Ca2+]i level was measured by spectrofluorimetry in fura-2-loaded glomus cells dissociated from the carotid bodies.
Localization (response) of Ang IV in glomus
9) Confidence 0.72 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.48 Pain Relevance 0.05
It has also been demonstrated that high affinity binding sites for Ang IV, known as the angiotensin AT4 receptor, localized in various tissues such as the rat brain and kidney [12–14].
Localization (localized) of Ang IV in kidney
10) Confidence 0.72 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.39 Pain Relevance 0
Collectively, these observations support the existence of a wide pre- and postsynaptic distribution of ANG II AT1 receptors in neonatal ventral spinal cord that are capable of influencing both inhibitory and excitatory neurotransmission.
Localization (distribution) of ANG II in spinal cord associated with spinal cord
11) Confidence 0.72 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 16061493 Disease Relevance 0 Pain Relevance 0.44
This study determined the significance of the latter mechanism for angiotensin-induced catecholamine release in the pithed rat.
Localization (release) of angiotensin associated with catecholamine
12) Confidence 0.71 Published 2002 Journal Hypertension Section Abstract Doc Link 12215478 Disease Relevance 0 Pain Relevance 0.18
We investigated the uterotonic and PG-releasing actions of OT, angiotensin II (AT) and methacholine (MC) in isolated pregnant rat uteri.
Localization (releasing) of angiotensin II
13) Confidence 0.71 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7205617 Disease Relevance 0.07 Pain Relevance 0.07
Ang II (10(-6) mol.L(-1))-induced transient Cai++ mobilization from internal stores was assessed in the absence of external Ca++.
Localization (mobilization) of Ang II in external
14) Confidence 0.70 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15085058 Disease Relevance 0 Pain Relevance 0.13
However, our previous studies examining angiotensin II-induced adenosine release were performed under nonphysiological conditions involving, in one case, perfusion of rat lungs with a salt solution and, in another case, collection of plasma adenosine samples from anesthetized, laparotomized rats.
Localization (release) of angiotensin II in plasma associated with adenocard
15) Confidence 0.70 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1714001 Disease Relevance 0.09 Pain Relevance 0.33
Moreover, nitrendipine increased Na+ excretion of conscious, ANG II-hypertensive rats but not of controls.
Localization (excretion) of ANG II associated with hypertension
16) Confidence 0.69 Published 1985 Journal Hypertension Section Abstract Doc Link 3158602 Disease Relevance 0.86 Pain Relevance 0.08
To further show the link between ionic stimulation and angiotensin release and determine the potential role of extracellular sodium ions on angiotensin release, cultures were incubated with the Na(+)-channel blocker tetrodotoxin (300 nM TTX) prior to maximal stimulation with 60 mM KCl/5 mM CaCl2 in the presence of the channel antagonist.
Spec (determine) Localization (release) of angiotensin associated with tetrodotoxin and antagonist
17) Confidence 0.69 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1617438 Disease Relevance 0 Pain Relevance 0.20
In this study, we utilized dissociated cell cultures of fetal rat brain to examine the cellular and ionic properties of angiotensin release.
Spec (examine) Localization (release) of angiotensin in brain
18) Confidence 0.69 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1617438 Disease Relevance 0 Pain Relevance 0.05
W-7, which displays specificity for inhibition of the Ca2+/calmodulin complex below 0.2 mM, decreased angiotensin release in a dose-dependent manner.
Localization (release) of angiotensin
19) Confidence 0.69 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1617438 Disease Relevance 0 Pain Relevance 0.16
To further show the link between ionic stimulation and angiotensin release and determine the potential role of extracellular sodium ions on angiotensin release, cultures were incubated with the Na(+)-channel blocker tetrodotoxin (300 nM TTX) prior to maximal stimulation with 60 mM KCl/5 mM CaCl2 in the presence of the channel antagonist.
Localization (release) of angiotensin associated with tetrodotoxin and antagonist
20) Confidence 0.69 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1617438 Disease Relevance 0 Pain Relevance 0.17

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