INT206600

Context Info Confidence 0.55 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.54 Pain Relevance 0.83

cell proliferation (Gnb1) signal transduction (Gnb1) GTPase activity (Gnb1) signal transducer activity (Gnb1)

Anatomy Link Frequency locus coeruleus 1 Gnb1 (Mus musculus)

Pain Link Frequency Relevance Heat withdrawal 2 99.96 Morphine 49 99.74 Locus ceruleus 3 99.68 cocaine 9 94.92 Dopamine 11 86.56 Nucleus accumbens 24 83.84 Ventral tegmentum 5 83.44 Physical dependence 1 80.72 opiate 2 78.88 Catechol-O-methyltransferase 46 17.36

Disease Link Frequency Relevance Heat Urological Neuroanatomy 10 82.72 Drug Dependence 3 80.72 Sprains And Strains 83 79.44 Depression 5 5.00 Pain 2 5.00 Adhesions 2 5.00 Dislocations 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In a recent study examining genes that show altered expression four hours after naltrexone-induced morphine withdrawal, Gnb1 was downregulated in the locus coeruleus (LC) of C57 mice [34].

Negative_regulation (downregulated) of Gnb1 in locus coeruleus associated with locus ceruleus, withdrawal and morphine

1) Confidence 0.55 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.54 Pain Relevance 0.83

General Comments

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