INT206600

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.54
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gnb1) signal transduction (Gnb1) GTPase activity (Gnb1)
signal transducer activity (Gnb1)
Anatomy Link Frequency
locus coeruleus 1
Gnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 2 99.96 Very High Very High Very High
Morphine 49 99.74 Very High Very High Very High
Locus ceruleus 3 99.68 Very High Very High Very High
cocaine 9 94.92 High High
Dopamine 11 86.56 High High
Nucleus accumbens 24 83.84 Quite High
Ventral tegmentum 5 83.44 Quite High
Physical dependence 1 80.72 Quite High
opiate 2 78.88 Quite High
Catechol-O-methyltransferase 46 17.36 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 10 82.72 Quite High
Drug Dependence 3 80.72 Quite High
Sprains And Strains 83 79.44 Quite High
Depression 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a recent study examining genes that show altered expression four hours after naltrexone-induced morphine withdrawal, Gnb1 was downregulated in the locus coeruleus (LC) of C57 mice [34].
Negative_regulation (downregulated) of Gnb1 in locus coeruleus associated with locus ceruleus, withdrawal and morphine
1) Confidence 0.55 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.54 Pain Relevance 0.83

General Comments

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