INT206601

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 3.60
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gnb1) signal transduction (Gnb1) GTPase activity (Gnb1)
signal transducer activity (Gnb1)
Anatomy Link Frequency
brain 1
Gnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 368 100.00 Very High Very High Very High
cocaine 72 99.68 Very High Very High Very High
Morphine 392 99.32 Very High Very High Very High
Nucleus accumbens 192 98.32 Very High Very High Very High
opiate 16 95.80 Very High Very High Very High
Physical dependence 8 95.36 Very High Very High Very High
Ventral tegmentum 40 93.36 High High
Dopamine 88 92.00 High High
Locus ceruleus 24 87.08 High High
withdrawal 16 84.00 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 80 99.68 Very High Very High Very High
Sprains And Strains 664 99.12 Very High Very High Very High
Drug Dependence 24 95.36 Very High Very High Very High
Pain 16 47.28 Quite Low
Depression 40 28.48 Quite Low
Adhesions 16 5.00 Very Low Very Low Very Low
Dislocations 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altered expression of Gnb1 was confirmed by QPCR.
Gene_expression (expression) of Gnb1
1) Confidence 0.73 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.32 Pain Relevance 0.40
In our studies, Gnb1 expression, as measured by QPCR, showed modestly increased (~50%) expression in both strains in the presence of morphine.
Gene_expression (expression) of Gnb1 associated with sprains and strains and morphine
2) Confidence 0.73 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.43 Pain Relevance 0.49
Interestingly, Gnb1 expression has been shown to be up-regulated in the NAC in response to cocaine administration in mouse [31] and rat [32], and in response to amphetamine [31] and methamphetamine [33] treatment in the mouse.
Gene_expression (expression) of Gnb1 associated with nucleus accumbens and cocaine
3) Confidence 0.73 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.41 Pain Relevance 0.56
Antisense disruption of Gnb1 expression blocks cocaine-induced sensitization, but without affecting the acute responses to cocaine [31].
Gene_expression (expression) of Gnb1 associated with cocaine
4) Confidence 0.73 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.49 Pain Relevance 0.75
A role for Gnb1 expression in responses to multiple drugs of abuse is supported by the expression data.
Gene_expression (expression) of Gnb1
5) Confidence 0.73 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.59 Pain Relevance 0.81
Data mining of expression and behavioral data indicates that both Gnb1 and Comt expression correlate with aspects of drug response in C57/DBA recombinant inbred strains.
Gene_expression (expression) of Gnb1 associated with catechol-o-methyltransferase and sprains and strains
6) Confidence 0.57 Published 2007 Journal BMC Genomics Section Abstract Doc Link PMC1851712 Disease Relevance 0.67 Pain Relevance 0.46
Moreover, in that study Gnb1 also showed decreased expression in the FC in the DBA strain.
Gene_expression (expression) of Gnb1 associated with urological neuroanatomy and sprains and strains
7) Confidence 0.49 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.44 Pain Relevance 0.40
More generally, several genes showing altered expression in controls in our study (including Prdrx2, Comt, Zfp197, Gabra2, Gnb1, Sgne1, Glo1, and additional ESTs) also showed similar alterations in that study, when analyzed with both MAS5 and dChip, even though the focus was on an independent brain area.
Spec (analyzed) Gene_expression (expression) of Gnb1 in brain associated with catechol-o-methyltransferase
8) Confidence 0.25 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.25 Pain Relevance 0.25

General Comments

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