INT20664

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 2010
Negated 5
Speculated 4
Reported most in Body
Documents 60
Total Number 63
Disease Relevance 35.27
Pain Relevance 9.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
plasma 3
muscle 3
kidney 2
coronary artery 2
platelet 1
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 15 100.00 Very High Very High Very High
Migraine 150 99.80 Very High Very High Very High
bradykinin 85 99.56 Very High Very High Very High
peptic ulcer disease 60 99.36 Very High Very High Very High
Opioid 5 99.14 Very High Very High Very High
antagonist 99 99.04 Very High Very High Very High
Dopamine 8 98.36 Very High Very High Very High
metalloproteinase 59 98.32 Very High Very High Very High
Substantia nigra 3 97.92 Very High Very High Very High
opiate 10 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 332 100.00 Very High Very High Very High
Obstructive Sleep Apnea 163 100.00 Very High Very High Very High
Pre-eclampsia 336 99.98 Very High Very High Very High
Renal Disease 79 99.98 Very High Very High Very High
Myocardial Infarction 263 99.96 Very High Very High Very High
Headache 195 99.80 Very High Very High Very High
Fatigue 42 99.80 Very High Very High Very High
Disease 279 99.36 Very High Very High Very High
Ulcers 59 99.36 Very High Very High Very High
Sepsis 99 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For inclusion, studies had to involve unrelated women and examine the association between the ACE-I/D polymorphism and preeclampsia.
ACE Spec (examine) Binding (association) of associated with pre-eclampsia
1) Confidence 0.48 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1716194 Disease Relevance 0.74 Pain Relevance 0
ACE I allele is associated with resistance and endurance performance.
ACE I allele Binding (associated) of
2) Confidence 0.48 Published 2005 Journal Int. J. Cardiol. Section Abstract Doc Link 15686789 Disease Relevance 0.46 Pain Relevance 0.15
Nine studies investigated the association of the ACE D/I polymorphism with migraine.
ACE Binding (association) of
3) Confidence 0.47 Published 2010 Journal Headache Section Body Doc Link 19925624 Disease Relevance 0.12 Pain Relevance 0
Evaluation of enantioselective binding of basic drugs to plasma by ACE.
ACE Binding (binding) of in plasma
4) Confidence 0.47 Published 2007 Journal Electrophoresis Section Title Doc Link 17661317 Disease Relevance 0 Pain Relevance 0.17
Angiotensin converting enzyme, serotonin, and benzodiazepine II binding are virtually unaltered.
Angiotensin converting enzyme Binding (binding) of associated with serotonin
5) Confidence 0.43 Published 1986 Journal Ann. Neurol. Section Abstract Doc Link 3019228 Disease Relevance 0.17 Pain Relevance 0.67
Binding to nigral angiotensin converting enzyme is also dense, whereas more modest densities of kappa-opiate, dopamine, and serotonin receptors are noted.
angiotensin converting enzyme Binding (Binding) of associated with dopamine, opiate and serotonin
6) Confidence 0.43 Published 1986 Journal Ann. Neurol. Section Abstract Doc Link 3019228 Disease Relevance 0.16 Pain Relevance 0.66
A large range of biofunctional peptides have been isolated from food proteins including opioid, immunomodulatory, antimicrobial, mineral binding, growth and muscle stimulating, anti-cancer, proteinase and angiotensin converting enzyme (ACE, EC 3.4.15.1) inhibitory peptides.
angiotensin converting enzyme Binding (binding) of in muscle associated with cancer and opioid
7) Confidence 0.41 Published 2007 Journal Curr. Pharm. Des. Section Abstract Doc Link 17430180 Disease Relevance 0.10 Pain Relevance 0.20
An additive model (per-D-allele) revealed a null association between the ACE-I/D variant and preeclampsia risk (crude OR = 0.95 [95% CI, 0.81–1.10]).
ACE Binding (association) of associated with pre-eclampsia
8) Confidence 0.37 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1716194 Disease Relevance 0.27 Pain Relevance 0
The principal a priori hypothesis was that the association between the ACE-I/D polymorphism and preeclampsia follows an additive model according to the number of D alleles.
ACE Binding (association) of associated with pre-eclampsia
9) Confidence 0.37 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1716194 Disease Relevance 0.10 Pain Relevance 0
Power calculation for the association between ACE polymorphisms and migraine was performed with the method described by Altman with correction for unequal sample sizes [15].
ACE Binding (association) of associated with migraine
10) Confidence 0.37 Published 2008 Journal BMC Neurol Section Body Doc Link PMC2311324 Disease Relevance 0.29 Pain Relevance 0.29
For the association between ACE polymorphisms and drug response, we performed a one sample two tailed test with alpha = 0.05.


ACE Binding (association) of
11) Confidence 0.37 Published 2008 Journal BMC Neurol Section Body Doc Link PMC2311324 Disease Relevance 0.33 Pain Relevance 0.33
Association of ACE gene polymorphisms with coronary artery disease in a northern area of Japan.
ACE Binding (Association) of in coronary artery associated with coronary artery disease
12) Confidence 0.37 Published 1995 Journal Jpn Heart J Section Title Doc Link 8558760 Disease Relevance 0.97 Pain Relevance 0.06
This radioligand binds specifically and with high affinity to angiotensin converting enzyme and also exhibited these properties in binding to slide-mounted sections of human basal ganglia.
angiotensin converting enzyme Binding (binds) of in basal ganglia
13) Confidence 0.37 Published 1990 Journal J. Comp. Neurol. Section Abstract Doc Link 2153714 Disease Relevance 0 Pain Relevance 0.17
These data suggest a potential protective association of ACE inhibitors for cancer and peptic ulcer disease in patients with diabetes.
ACE Binding (association) of associated with diabetes mellitus, cancer, peptic ulcer disease and disease
14) Confidence 0.37 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2632632 Disease Relevance 0.67 Pain Relevance 0.24
We are aware of no prior studies of the association between ACE inhibitors and PUD in humans, but Sugimoto et al. [27] suggested that ACE gene polymorphisms were associated with cancer risk and gastric ulcers in Japan.
ACE Neg (no) Binding (association) of associated with cancer, peptic ulcer disease and peptic ulcer
15) Confidence 0.37 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2632632 Disease Relevance 1.54 Pain Relevance 0.23
Very few reports have looked at the association between ACE inhibitors and peptic ulcers.
ACE Binding (association) of associated with ulcers
16) Confidence 0.37 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2632632 Disease Relevance 1.56 Pain Relevance 0.26
A large range of biofunctional peptides have been isolated from food proteins including opioid, immunomodulatory, antimicrobial, mineral binding, growth and muscle stimulating, anti-cancer, proteinase and angiotensin converting enzyme (ACE, EC 3.4.15.1) inhibitory peptides.
ACE Binding (binding) of in muscle associated with cancer and opioid
17) Confidence 0.37 Published 2007 Journal Curr. Pharm. Des. Section Abstract Doc Link 17430180 Disease Relevance 0.10 Pain Relevance 0.20
Our publication in 1984 dealt with ACE and NEP purified to homogeneity from human kidney.
ACE Binding (dealt) of in kidney
18) Confidence 0.37 Published 2004 Journal Peptides Section Abstract Doc Link 15134871 Disease Relevance 0 Pain Relevance 0.37
The remarkable improvement in the long-term prognosis of atherosclerotic patients with increased cardiovascular risk might be the clinical result of the contribution made by ACE inhibition in the vascular wall.
ACE Neg (inhibition) Spec (might) Binding (inhibition) of associated with atherosclerosis
19) Confidence 0.37 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.91 Pain Relevance 0.15
Thus, considering this like a drug class effect, the ACE-I would be recommended in patients with PAD.
ACE-I Binding (recommended) of associated with peripheral arterial disease
20) Confidence 0.37 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.79 Pain Relevance 0.09

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