INT20665

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Context Info
Confidence 0.78
First Reported 1980
Last Reported 2011
Negated 7
Speculated 2
Reported most in Body
Documents 87
Total Number 89
Disease Relevance 51.71
Pain Relevance 14.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
blood 5
cleavage 2
neuroepithelial cells 2
lungs 2
epithelial cells 2
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 148 100.00 Very High Very High Very High
aspirin 50 100.00 Very High Very High Very High
opioid receptor 1 100.00 Very High Very High Very High
antagonist 181 99.96 Very High Very High Very High
beta blocker 119 99.96 Very High Very High Very High
substance P 22 99.96 Very High Very High Very High
peptic ulcer disease 45 99.80 Very High Very High Very High
Calcium channel 39 99.72 Very High Very High Very High
Inflammation 384 99.44 Very High Very High Very High
rheumatoid arthritis 71 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 606 100.00 Very High Very High Very High
Myocardial Infarction 539 100.00 Very High Very High Very High
Cv Unclassified Under Development 62 100.00 Very High Very High Very High
Vascular Dementia 1 100.00 Very High Very High Very High
Metabolic Syndrome 165 99.96 Very High Very High Very High
Injury 584 99.92 Very High Very High Very High
Sarcoidosis 175 99.84 Very High Very High Very High
Pancreatitis 10 99.84 Very High Very High Very High
Pulmonary Hypertension 61 99.82 Very High Very High Very High
Anaemia 16 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some ACE was detectable in the mucus material of gland and duct lumens but not in gland cells themselves.
Neg (not) Gene_expression (detectable) of ACE in lumens
1) Confidence 0.78 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 8049077 Disease Relevance 0 Pain Relevance 0.11
Increased expression of tissue ACE has been found in the vasculature of subjects with hypertension and in the microvasculature throughout an atherosclerotic plaque, suggesting that the accumulation of ACE in the plaque contributes to increased local production of Ang II (Gibbons 1995; Diet et al 1996).
Gene_expression (expression) of ACE in vasculature associated with atherosclerotic plaque and pressure and volume under development
2) Confidence 0.76 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.60 Pain Relevance 0.11
In human, ACE is expressed as a somatic isoform in endothelial, epithelial, and neuroepithelial cells and as a smaller isoform only in male germinal cells.
Gene_expression (expressed) of ACE in neuroepithelial cells
3) Confidence 0.74 Published 2010 Journal Bioinorganic Chemistry and Applications Section Body Doc Link PMC2902127 Disease Relevance 0.48 Pain Relevance 0.08
A cumulative synthesis of ACE-I/D variants and preeclampsia revealed substantial instability of the genetic effect over time, with studies published between 1996 and 1997 demonstrating the most protective effect, immediately followed by studies published in 1998 and 1999 indicating the most significant results in the opposite direction.
Gene_expression (synthesis) of ACE associated with pre-eclampsia
4) Confidence 0.67 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1716194 Disease Relevance 0.21 Pain Relevance 0
Univariate statistics revealed that as compared to tertiary care hospital discharge prescriptions there was a gradual attrition of prescriptions of aspirin, beta blockers, ACE inhibitors/ARBs and statins in chronic tertiary care, secondary care, and primary care, respectively (?
Gene_expression (/) of ACE associated with aspirin and beta blocker
5) Confidence 0.67 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788593 Disease Relevance 0 Pain Relevance 0.29
Serum angiotensin converting enzyme levels in pancreatic diseases.
Gene_expression (levels) of angiotensin converting enzyme associated with pancreatitis
6) Confidence 0.67 Published 2008 Journal Hepatogastroenterology Section Title Doc Link 19102399 Disease Relevance 0.19 Pain Relevance 0.08
There was no correlation between ACE levels and tumor size.
Gene_expression (levels) of ACE
7) Confidence 0.67 Published 2008 Journal Hepatogastroenterology Section Body Doc Link 19102399 Disease Relevance 0.07 Pain Relevance 0
Angiotensin converting enzyme is heterogeneously distributed in the caudate nucleus and putamen, with distinct patches of high concentration surrounded by a matrix of diffuse, lower levels.
Gene_expression (distributed) of Angiotensin converting enzyme in caudate nucleus
8) Confidence 0.67 Published 1990 Journal J. Comp. Neurol. Section Abstract Doc Link 2153714 Disease Relevance 0.09 Pain Relevance 0.36
These animal studies support the findings that ACE inhibitors may protect against PUD.
Gene_expression (protect) of ACE associated with peptic ulcer disease
9) Confidence 0.67 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2632632 Disease Relevance 1.66 Pain Relevance 0.23
The mechanisms of the observed associations between ACE inhibition and the two diagnoses are unknown.
Gene_expression (inhibition) of ACE
10) Confidence 0.67 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2632632 Disease Relevance 1.61 Pain Relevance 0.27
Third, multiple potential confounders were assessed and found to have no significant effect on the apparent associations between ACE inhibition and PUD and cancer.
Neg (inhibition) Gene_expression (inhibition) of ACE associated with cancer and peptic ulcer disease
11) Confidence 0.67 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2632632 Disease Relevance 1.00 Pain Relevance 0.23
HPLC analysis showed that ACE cleaved SP at Phe(8)-Gly(9) and Gly(9)-Leu(10) to release C-terminal tri- and dipeptide (ratio = 4:1).
Gene_expression (cleaved) of ACE associated with substance p
12) Confidence 0.66 Published 2004 Journal Peptides Section Abstract Doc Link 15134871 Disease Relevance 0 Pain Relevance 0.71
Vasculoprotective effects of ACE-inhibitors
Gene_expression (effects) of ACE
13) Confidence 0.66 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.71 Pain Relevance 0.21
They also indicate that intramuscular kinin peptides levels, and ACE activity, may contribute to muscle pain.
Gene_expression (levels) of ACE in muscle associated with pain and myalgia
14) Confidence 0.66 Published 2005 Journal J. Appl. Physiol. Section Abstract Doc Link 15475593 Disease Relevance 0.41 Pain Relevance 0.47
Other non-viral gene delivery systems that have potential in the treatment of RA are the artificial chromosome expression (ACE) system and the sleeping beauty (SB) transposon system.
Gene_expression (expression) of ACE associated with rheumatoid arthritis
15) Confidence 0.65 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 0.71 Pain Relevance 0.32
Thus, at least an attempt at using statins and ACEI/ARB in post-MI patients can be expected in probably >95% of patients.
Gene_expression (expected) of ACEI associated with myocardial infarction
16) Confidence 0.65 Published 2007 Journal Eur J Epidemiol Section Body Doc Link PMC2249618 Disease Relevance 0.88 Pain Relevance 0.05
At hospital discharge, there were similar prescription rates for aspirin, ACE-inhibitor/ARB, and ?
Gene_expression (prescription) of ACE associated with aspirin
17) Confidence 0.65 Published 2007 Journal BMC Health Serv Res Section Body Doc Link PMC2082028 Disease Relevance 1.42 Pain Relevance 0.09
M captopril (to inhibit any ACE cleavage of DAGNPG) in a volume of 200 ?
Gene_expression (cleavage) of ACE in cleavage
18) Confidence 0.65 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0.04
Presence and biochemical properties of a molluscan invertebrate angiotensin-converting enzyme.
Gene_expression (Presence) of angiotensin-converting enzyme
19) Confidence 0.65 Published 1997 Journal Regul. Pept. Section Title Doc Link 9178346 Disease Relevance 0 Pain Relevance 0.13
Potential risk factors include hyperkalemia, anaphylactoid reaction with AN69 membranes (particularly ACE inhibitors), and aggravation of renal anemia. beta-blockers decrease not only mortality, blood pressure (BP), and ventricular arrhythmias, but also improve left ventricular function in ESRD patients.
Gene_expression (aggravation) of ACE in blood associated with chronic renal failure, anaemia, hyperkalemia, beta blocker and anaphylaxis
20) Confidence 0.65 Published 2004 Journal Semin Dial Section Abstract Doc Link 15250920 Disease Relevance 1.03 Pain Relevance 0.12

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