INT206683

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.54
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (KDR) cytoplasmic membrane-bounded vesicle (KDR) plasma membrane (KDR)
nucleus (KDR) cytoplasm (KDR)
Anatomy Link Frequency
epithelium 2
KDR (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 5 81.60 Quite High
cva 7 13.20 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 3 95.96 Very High Very High Very High
Age-related Macular Degeneration 82 95.84 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 1 95.70 Very High Very High Very High
Toxicity 10 81.56 Quite High
Sarcoma 78 80.20 Quite High
Apoptosis 2 72.84 Quite High
Renal Failure 2 69.64 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 67.56 Quite High
Wound Healing 1 45.40 Quite Low
Disease 8 42.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blocking the interaction between VEGF and Flk-1/KDR can abolish VEGF induced proliferation.
Negative_regulation (Blocking) of KDR Binding (interaction) of
1) Confidence 0.34 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC1852096 Disease Relevance 1.03 Pain Relevance 0
Blocking the interaction between VEGF and Flk-1/KDR can abolish VEGF induced proliferation.
Negative_regulation (Blocking) of Flk-1 Binding (interaction) of
2) Confidence 0.34 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC1852096 Disease Relevance 1.03 Pain Relevance 0
Promising therapies in development include: other VEGF inhibitors; VEGF traps; small interfering RNA (siRNA) to block translation/production of VEGF or its receptor; pigment epithelium-derived factors (PEDF) to counterbalance the angiogenic effects of VEGF; and tyrosine kinase inhibitors to block signal transduction following VEGFR binding.


Negative_regulation (block) of VEGFR Binding (binding) of in epithelium associated with tumor necrosis factor receptor-associated periodic syndrome
3) Confidence 0.18 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699647 Disease Relevance 0.47 Pain Relevance 0.08

General Comments

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