INT206695

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.77
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (GFM1) intracellular (GFM1) GTPase activity (GFM1)
GFM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 1 21.52 Low Low
cytokine 20 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 49 96.48 Very High Very High Very High
Hypersensitivity 6 87.92 High High
Colon Cancer 2 84.36 Quite High
Cancer 54 82.44 Quite High
Non-small-cell Lung Cancer 13 69.00 Quite High
Hepatitis 4 68.48 Quite High
Disease 46 63.12 Quite High
Malignant Neoplastic Disease 8 50.00 Quite Low
Residual Neoplasm 2 43.60 Quite Low
Advanced Or Metastatic Breast Cancer 1 39.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another novel anti-EGFR antibody, mAb 806, is active against cell lines expressing the mutant variant EGFRvIII as well as cell lines in which wild type EGFR is over-expressed.48 Cetuximab, nimotuzumab, panitumumab and matuzumab all prevent ligand binding via interactions with EGFR domain III, and mAb 806 interferes with receptor function via interactions with domain II.49–52 The clinical significance of these molecular interactions of antibody and receptor is unknown and is the subject of ongoing basic research.


Gene_expression (expressing) of EGF
1) Confidence 0.58 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921255 Disease Relevance 0.33 Pain Relevance 0
Expression of the EGFR alternative transcript variant, EGFRvIII, could not be detected by RT-PCR (data not shown).
Gene_expression (Expression) of EGF
2) Confidence 0.26 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2970593 Disease Relevance 0.37 Pain Relevance 0
Anti-HBsAg titres measured in mIU/mL were expressed as geometric mean titres (GMT) for each group.
Gene_expression (expressed) of GMT
3) Confidence 0.02 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.07 Pain Relevance 0

General Comments

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