INT206695

Context Info Confidence 0.58 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.77 Pain Relevance 0

mitochondrion (GFM1) intracellular (GFM1) GTPase activity (GFM1)

GFM1 (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 1 21.52 cytokine 20 5.00 palliative 2 5.00 Inflammation 2 5.00 Pain 2 5.00 alcohol 2 5.00 agonist 2 5.00 headache 2 5.00 methotrexate 1 5.00 addiction 1 5.00

Disease Link Frequency Relevance Heat Lung Cancer 49 96.48 Hypersensitivity 6 87.92 Colon Cancer 2 84.36 Cancer 54 82.44 Non-small-cell Lung Cancer 13 69.00 Hepatitis 4 68.48 Disease 46 63.12 Malignant Neoplastic Disease 8 50.00 Residual Neoplasm 2 43.60 Advanced Or Metastatic Breast Cancer 1 39.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Another novel anti-EGFR antibody, mAb 806, is active against cell lines expressing the mutant variant EGFRvIII as well as cell lines in which wild type EGFR is over-expressed.48 Cetuximab, nimotuzumab, panitumumab and matuzumab all prevent ligand binding via interactions with EGFR domain III, and mAb 806 interferes with receptor function via interactions with domain II.49–52 The clinical significance of these molecular interactions of antibody and receptor is unknown and is the subject of ongoing basic research.

Gene_expression (expressing) of EGF

1) Confidence 0.58 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921255 Disease Relevance 0.33 Pain Relevance 0

Expression of the EGFR alternative transcript variant, EGFRvIII, could not be detected by RT-PCR (data not shown).

Gene_expression (Expression) of EGF

2) Confidence 0.26 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2970593 Disease Relevance 0.37 Pain Relevance 0

Anti-HBsAg titres measured in mIU/mL were expressed as geometric mean titres (GMT) for each group.

Gene_expression (expressed) of GMT

3) Confidence 0.02 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.07 Pain Relevance 0

General Comments

This test has worked.