INT206696

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.44
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) nucleus (TH1L)
Anatomy Link Frequency
T cells 4
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 147 100.00 Very High Very High Very High
Catecholamine 6 99.46 Very High Very High Very High
Inflammation 138 95.60 Very High Very High Very High
Inflammatory response 12 40.24 Quite Low
tolerance 5 31.56 Quite Low
Potency 4 29.44 Quite Low
vagus nerve 2 18.64 Low Low
Inflammatory mediators 2 13.44 Low Low
Endogenous opioid 2 5.84 Low Low
antagonist 35 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 22 100.00 Very High Very High Very High
Asthma 317 99.84 Very High Very High Very High
Disease 249 99.76 Very High Very High Very High
Crohn's Disease 4 98.32 Very High Very High Very High
Sprains And Strains 17 97.86 Very High Very High Very High
Stress 121 96.72 Very High Very High Very High
INFLAMMATION 149 95.60 Very High Very High Very High
Respiratory Syncytial Virus 1 92.60 High High
Pneumonia 7 90.44 High High
Eosinophilia 19 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In groups receiving IMP321, an increase in the frequency of specific CD4+ T cells producing Th1-type cytokines was observed in 2 subjects (25 %) in the 3 and 10 ?
Regulation (frequency) of Gene_expression (producing) of Th1-type in T cells associated with cytokine
1) Confidence 0.20 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.06 Pain Relevance 0.13
Glucocorticoids and catecholamines mediate a Th2 shift by up-regulating Th2 cytokine production and also by suppressing APCs and Th1 cytokine synthesis [34, 35].
Regulation (regulating) of Gene_expression (synthesis) of Th1 associated with catecholamine and cytokine
2) Confidence 0.16 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 1.29 Pain Relevance 0.54
Other modulators of the Th1/Th2 balance in asthma
Regulation (modulators) of Gene_expression (balance) of Th1 associated with asthma
3) Confidence 0.14 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.42 Pain Relevance 0.20
Strains of the genus Bifidobacterium have been shown to polarized Th2/Th1 responses in a specific manner, thereby modulating unbalanced cytokine production characteristic of either Th2-type (e.g. allergy) or Th1-type diseases (e.g.
Regulation (modulating) of Gene_expression (production) of Th1 associated with hypersensitivity, disease, sprains and strains and cytokine
4) Confidence 0.08 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2635381 Disease Relevance 1.34 Pain Relevance 0.21
Activated CD4+ T cells enact a Th1 response, secreting IFN-?
Regulation (enact) of Gene_expression (response) of Th1 in T cells
5) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.33 Pain Relevance 0.18

General Comments

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