INT206705
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Bevacizumab prevents interaction of VEGF with VEGFR1 (FLT-1) and VEGFR2 (KDR) on the surface of endothelial cells to inhibit angiogenesis. | |||||||||||||||
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Bevacizumab prevents interaction of VEGF with VEGFR1 (FLT-1) and VEGFR2 (KDR) on the surface of endothelial cells to inhibit angiogenesis. | |||||||||||||||
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However, binding of VEGF to cell transmembrane receptors is reduced by a soluble circulating form of Flt-1 (sFlt-1), which is generated by alternative splicing. | |||||||||||||||
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General Comments
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