INT206705

Context Info Confidence 0.11 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.90 Pain Relevance 0

cytoplasm (FLT1, VEGFA) extracellular space (FLT1, VEGFA) extracellular region (FLT1, VEGFA) cell differentiation (FLT1) endosome (FLT1) Golgi apparatus (FLT1)

Anatomy Link Frequency endothelial cells 4 FLT1 (Homo sapiens) VEGFA (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 1 22.04 bradykinin 11 20.32 metalloproteinase 6 5.00 Chronic pancreatitis 4 5.00 chemokine 2 5.00 Glutamate 2 5.00 imagery 2 5.00 antagonist 2 5.00 aspirin 1 5.00 fibrosis 1 5.00

Disease Link Frequency Relevance Heat Colon Cancer 30 97.08 Pre-eclampsia 33 94.04 Apoptosis 10 81.40 Cancer 214 72.88 Advanced Or Metastatic Breast Cancer 2 65.36 Syndrome 4 61.20 Hypertension 5 60.00 Proteinuria 1 58.88 Breast Cancer 20 57.00 Solid Tumor 6 50.96

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Key:

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Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Bevacizumab prevents interaction of VEGF with VEGFR1 (FLT-1) and VEGFR2 (KDR) on the surface of endothelial cells to inhibit angiogenesis.

Negative_regulation (prevents) of VEGFR1 Binding (interaction) of VEGF in endothelial cells

1) Confidence 0.11 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 0.74 Pain Relevance 0

Bevacizumab prevents interaction of VEGF with VEGFR1 (FLT-1) and VEGFR2 (KDR) on the surface of endothelial cells to inhibit angiogenesis.

Negative_regulation (prevents) of FLT-1 Binding (interaction) of VEGF in endothelial cells

2) Confidence 0.11 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 0.74 Pain Relevance 0

However, binding of VEGF to cell transmembrane receptors is reduced by a soluble circulating form of Flt-1 (sFlt-1), which is generated by alternative splicing.

Negative_regulation (reduced) of Flt-1 Binding (binding) of VEGF

3) Confidence 0.09 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.42 Pain Relevance 0

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