INT206705

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (FLT1, VEGFA) extracellular space (FLT1, VEGFA) extracellular region (FLT1, VEGFA)
cell differentiation (FLT1) endosome (FLT1) Golgi apparatus (FLT1)
Anatomy Link Frequency
endothelial cells 4
FLT1 (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 22.04 Low Low
bradykinin 11 20.32 Low Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 30 97.08 Very High Very High Very High
Pre-eclampsia 33 94.04 High High
Apoptosis 10 81.40 Quite High
Cancer 214 72.88 Quite High
Advanced Or Metastatic Breast Cancer 2 65.36 Quite High
Syndrome 4 61.20 Quite High
Hypertension 5 60.00 Quite High
Proteinuria 1 58.88 Quite High
Breast Cancer 20 57.00 Quite High
Solid Tumor 6 50.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bevacizumab prevents interaction of VEGF with VEGFR1 (FLT-1) and VEGFR2 (KDR) on the surface of endothelial cells to inhibit angiogenesis.
Negative_regulation (prevents) of VEGFR1 Binding (interaction) of VEGF in endothelial cells
1) Confidence 0.11 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 0.74 Pain Relevance 0
Bevacizumab prevents interaction of VEGF with VEGFR1 (FLT-1) and VEGFR2 (KDR) on the surface of endothelial cells to inhibit angiogenesis.
Negative_regulation (prevents) of FLT-1 Binding (interaction) of VEGF in endothelial cells
2) Confidence 0.11 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 0.74 Pain Relevance 0
However, binding of VEGF to cell transmembrane receptors is reduced by a soluble circulating form of Flt-1 (sFlt-1), which is generated by alternative splicing.
Negative_regulation (reduced) of Flt-1 Binding (binding) of VEGF
3) Confidence 0.09 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.42 Pain Relevance 0

General Comments

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