INT20673

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Context Info
Confidence 0.31
First Reported 1986
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 1.96
Pain Relevance 5.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CDS1) endoplasmic reticulum (CDS1) nucleotidyltransferase activity (CDS1)
Anatomy Link Frequency
brain 3
CDS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 52 100.00 Very High Very High Very High
Catecholamine 8 100.00 Very High Very High Very High
diclofenac 2 99.82 Very High Very High Very High
COX-2 inhibitor 38 98.28 Very High Very High Very High
methadone 1 97.24 Very High Very High Very High
Opioid 2 95.96 Very High Very High Very High
anesthesia 2 94.48 High High
addiction 2 92.96 High High
Paracetamol 5 92.08 High High
palliative 3 90.96 High High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 7 94.20 High High
Dyspnea 7 94.12 High High
Pain 1 90.48 High High
INFLAMMATION 10 90.00 High High
Sleep Disorders 5 77.12 Quite High
Hypertension 4 75.12 Quite High
Hypotension 4 75.00 Quite High
Cancer 2 75.00 Quite High
Cleft Palate 2 75.00 Quite High
Wound Healing 1 70.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CDS was associated with a higher rate of requests from patients or relatives for a hastened death and with a greater incidence of other end-of-life decisions containing some intent to end life by the doctor.
CDS Binding (associated) of
1) Confidence 0.31 Published 2010 Journal J Pain Symptom Manage Section Body Doc Link 19854611 Disease Relevance 0.08 Pain Relevance 0
This article examines the generalizability of the CDs to other substance-dependent patients.
CDs Binding (generalizability) of
2) Confidence 0.31 Published 2000 Journal Psychol Addict Behav Section Abstract Doc Link 10998954 Disease Relevance 0 Pain Relevance 0.36
A substance has been isolated from brain which potently inhibits the binding of clonidine to brain membranes (clonidine displacing substance, CDS).
CDS Binding (binding) of in brain associated with clonidine
3) Confidence 0.30 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3480808 Disease Relevance 0 Pain Relevance 0.31
A substance has been isolated from bovine brain which displaces 3H-clonidine binding to rat brain membranes (clonidine-displacing substance; CDS).
CDS Binding (binding) of in brain associated with clonidine
4) Confidence 0.30 Published 1986 Journal Life Sci. Section Abstract Doc Link 3007903 Disease Relevance 0.07 Pain Relevance 0.76
A silicone sheet was placed on the matrix or CDS and affixed with superglue.
CDS Binding (matrix) of
5) Confidence 0.29 Published 2008 Journal J Artif Organs Section Abstract Doc Link 19184287 Disease Relevance 0.35 Pain Relevance 0.09
The CDS-S was well received by the patients and completed in 2 minutes.
CDS Binding (completed) of
6) Confidence 0.27 Published 2006 Journal J Pain Symptom Manage Section Abstract Doc Link 16632083 Disease Relevance 0.81 Pain Relevance 0.13
CDS is a brain substance which is not a catecholamine (CA) and which displaces completely the binding of tritiated clonidine to brain membranes.
CDS Binding (binding) of in brain associated with catecholamine and clonidine
7) Confidence 0.24 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455173 Disease Relevance 0.14 Pain Relevance 0.57
In conclusion, our findings showed that the imidazoline-guanidinium receptive site is located mainly in the basolateral side of the tubular cell, recognizes CDS and is regulated by K+.
CDS Binding (recognizes) of
8) Confidence 0.13 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2153803 Disease Relevance 0 Pain Relevance 0.07
In terms of retention, all physicians trained from this program have remained in their posts, which local officials contribute to the initial selection of trainees for this program (those already working in rural areas who originated from these areas and have settled their families there) as well as the fact that the CDS is not recognized outside of Niger.
CDS Binding (recognized) of
9) Confidence 0.11 Published 2009 Journal World J Surg Section Body Doc Link PMC2746305 Disease Relevance 0 Pain Relevance 0.08
All tested betaCDs increased the apparent solubility of NEF according to a Higuchi AL type plot (except betaCD: AN type plot), which indicates the formation of 1:1 stoichiometry inclusion complexes. 1H-NMR and 13C-NMR experiments showed that complexation by CDs allowed an easy separation of the R and S enantiomers.
CDs Binding (complexation) of
10) Confidence 0.10 Published 2006 Journal Drug Dev Ind Pharm Section Abstract Doc Link 17090434 Disease Relevance 0 Pain Relevance 0.07
It has been suggested that agmatine (decarboxylated arginine) is an endogenous clonidine-displacing substance (CDS) which recognizes alpha 2-adrenoceptor and non-adrenoceptor, imidazoline binding sites.
CDS Binding (recognizes) of associated with clonidine
11) Confidence 0.10 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7715734 Disease Relevance 0 Pain Relevance 0.21
Agmatine, a decarboxylated derivative of arginine, also binds to both I-sites and alpha2-adrenoceptors (Li et al., 1994), and is, by definition, a CDS molecule. 4.
CDS Binding (binds) of
12) Confidence 0.07 Published 1998 Journal Gen. Pharmacol. Section Abstract Doc Link 9792210 Disease Relevance 0 Pain Relevance 0.28
These include: (a) classic CDS, a partially purified entity isolated by the criteria that it displaces binding ligands to alpha 2- and I-receptors; (b) immunoreactive (ir)-CDS, a moiety that binds to antibodies raised against clonidine, para-amino-clonidine, or idazoxan; and (c) agmatine. 2.
CDS Binding (binds) of associated with clonidine
13) Confidence 0.06 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7677340 Disease Relevance 0 Pain Relevance 0.43
Classic-CDS, not yet defined structurally, binds to I1, I2, and alpha 2-adrenergic receptors, is neither a peptide nor a catecholamine, and has purportedly a molecular weight of 588 Da.
CDS Neg (neither) Binding (binds) of associated with catecholamine
14) Confidence 0.06 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7677340 Disease Relevance 0 Pain Relevance 0.49
These include: (a) classic CDS, a partially purified entity isolated by the criteria that it displaces binding ligands to alpha 2- and I-receptors; (b) immunoreactive (ir)-CDS, a moiety that binds to antibodies raised against clonidine, para-amino-clonidine, or idazoxan; and (c) agmatine. 2.
CDS Binding (binds) of associated with clonidine
15) Confidence 0.06 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7677340 Disease Relevance 0 Pain Relevance 0.43
Functionalization with CDs rendered as highly cytocompatible materials as the starting ones, did not cause relevant changes in the water contact angle and the friction coefficient of PE and PP, but remarkably improved their capability to uptake diclofenac through formation of inclusion complexes with the CDs.
CDs Binding (formation) of associated with diclofenac
16) Confidence 0.04 Published 2009 Journal Int J Pharm Section Abstract Doc Link 19716868 Disease Relevance 0.18 Pain Relevance 0.22
Thus, (a) anti-PAC3 antiserum is specific for clonidine and closely related compounds, and (b) CDS may structurally resemble clonidine since it is recognized by this highly specific antiserum.
CDS Binding (recognized) of associated with clonidine
17) Confidence 0.02 Published 1988 Journal Neurosci. Lett. Section Abstract Doc Link 3347376 Disease Relevance 0.33 Pain Relevance 0.60
The analyses revealed an association between the CDS scores and the probability of receiving a COX-2 inhibitor, although no trend was observed.
CDS Neg (no) Binding (association) of associated with cox-2 inhibitor
18) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065326 Disease Relevance 0 Pain Relevance 0.60

General Comments

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